Grignard reagents

Grignard Reagents

Our unparalleled portfolio of Grignard Reagents are used in reactions such as Grignard reaction to form a new carbon-carbon bond.

Grignard Reagents

Our unparalleled portfolio of Grignard Reagents are used in reactions such as Grignard reaction to form a new carbon-carbon bond.

Mild Mg – Halogen Exchange

Substantial progress has been made in magnesium–halogen exchange reactions used for the preparation of functionalized Grignard reagents containing sensitive moieties such as ester or cyano groups.

Selective Metalation, Deprotonation, and Additions

Transformative reagents for selective metalation, deprotonation and nucleophilic additions have allowed for unprecedented selective converstions to reactive intermediates within a molecule which contains sensative functionalities under mild reactions.

Organolithium Reagents

Our organolithium reagents are critical to the successful formation of known bond formations (e.g. nucleophilic addition and substitution) and the development of new technologies in organic synthesis.

Selective 1,2-Additions with LaCl3·2LiCl

While the 1,2-addition of Grignard reagents to ketones is undoubtedly a powerful transformation, oftentimes selectivity issues arising from competitive alpha-deprotonation detract from the use of these reagents.

Organolithium Reagents

Our organolithium reagents are critical to the successful formation of known bond formations (e.g. nucleophilic addition and substitution) and the development of new technologies in organic synthesis.

Organozinc Reagents

We offer a diverse range of organozinc reagents for the formation of known bond formations and the development of new technologies in organic synthesis.

Chemical Synthesis

Browse our selection of synthetic chemistry products, including coupling, halogenation, Grignard, oxidation, protection, deprotection, reduction, organoaluminium, and organosilicon reagents.

Organozinc Reagents

We offer a diverse range of organozinc reagents for the formation of known bond formations and the development of new technologies in organic synthesis.

Selective Metalations

Selective Metalations using i-PrMgCl·LiCl and s-BuMgCl·LiCl

Chemical Synthesis

New Reagents for Selective Metalation, Deprotonation, and 1,2-Additions

Sigma-Aldrich.com presents an article concerning New Reagents for Selective Metalation, Deprotonation, and 1,2-Additions.

Organotin Reagents

Our offering organotin reagents and compounds are useful in the formation of known bond formations and the development of new technologies in organic synthesis.

Boronic Acids & Derivatives

We are pleased to provide a wide range of boronic acids & derivatives, including boronate esters, trifluoroborate salts, and MIDA boronate esters. All of our boronic acid derivatives are offered as alkyl, alkenyl, aryl and heteroaryl derivatives.

Organic Reaction Toolbox

An organic reaction toolbox provides structure-activity relationships for unique chemical reactions to optimally design and control small molecule synthesis.

Boronic Acids & Derivatives

We are pleased to provide a wide range of boronic acids & derivatives, including boronate esters, trifluoroborate salts, and MIDA boronate esters. All of our boronic acid derivatives are offered as alkyl, alkenyl, aryl and heteroaryl derivatives.

Soderquist Reagents

Sigma-Aldrich is pleased to add these new tools to our growing arsenal of C–C bond forming reagents.

PEPPSI™ Catalysts

Professor Mike Organ at York University, along with co-workers Dr. Chris O’Brien and Dr. Eric Kantchev, have developed an palladium N-heterocyclic-carbene (NHC) catalyst system. They reacted PdCl2with a bulky NHC ligand, 2,6-diisopropylphenyllimidazolium chloride (IPr), and an α-donating 3-chloropyridine ligand for

PEPPSI™ Catalysts

PEPPSI™ Catalysts are novel state-of-the-art catalyst that successfully performs cross-coupling niche reactions.

Super Silyl Protecting Groups

The super silyl group is a powerful tool for the synthetic chemist, showing great efficacy in various carbon–carbon bond forming reactions.

Solvias® Ligand Portfolio for Enantioselective Hydrogenation

Fluoroalkylation: Expansion of Togni Reagents

The fluoroalkylation toolbox now includes Togni reagents, hypervalent iodine perfluoroalkylation reagents, fluoroalkyl bromides, silanes, carboxylates, and sulfonyl fluorides for late stage fluoroalkylation.

Molecular Monolayers on Silicon Surfaces

This article briefly reviews the methods and mechanisms for the formation of molecular monolayers on silicon surfaces, the properties of these monolayers and current perspectives regarding their application in molecular electronic and sensing applications.

Fluoroalkylation: Expansion of Togni Reagents

The fluoroalkylation toolbox now includes Togni reagents, hypervalent iodine perfluoroalkylation reagents, fluoroalkyl bromides, silanes, carboxylates, and sulfonyl fluorides for late stage fluoroalkylation.

Organosilanes for Cross-coupling

Over the past several years, Pd-catalyzed cross-coupling of silicon compounds has rapidly gained acceptance as a suitable alternative to more commonly known methods such as: Stille (Sn), Kumada (Mg), Suzuki (B), and Negishi (Zn) cross-couplings.

Bottles & Cans

We offer a variety of packaging options for your application. Whether you need your solvent packaging in glass bottle, PVC coated bottle, Sure/Seal bottle or aluminum can, we package and solvent dispensing options to meet your needs.

Microreactor Technology

Within the past two decades, Microreactor Technology (MRT) has evolved from a highly advanced toy for chemical engineers to a versatile tool for chemical synthesis. Since the time of the founders of synthetic chemistry, like Justus von Liebig or Friedrich

Ellman's Sulfinamides

Ellman's sulfinamide is available in both enantiomeric and racemic forms for your research. This versatile and useful auxiliary has found extensive use both in academics and industry.

New Conducting and Semiconducting Polymers for Plastic Electronics

New conducting and semiconducting polymers for plastic electronics