P42800

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Showing 1-30 of 56 results for "P42800" within Papers

Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.

Lisheng Deng et al.

Journal of medicinal chemistry, 54(13), 4721-4734 (2011-05-13)

1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) is a novel target for developing new antibacterial (including antituberculosis) and antimalaria drugs. Forty-one lipophilic phosphonates, representing a new class of DXR inhibitors, were synthesized, among which 5-phenylpyridin-2-ylmethylphosphonic acid possesses the most activity against E. coli DXR

Ameliorating effect of chromium administration on hepatic glucose metabolism in streptozotocin-induced experimental diabetes.

Bhuvaneshwari Sundaram et al.

BioFactors (Oxford, England), 38(1), 59-68 (2012-01-31)

Chromium has been recognized as an essential trace element that plays an important role in carbohydrate metabolism. However, the molecular mechanisms involved in its action are not clear. This study was undertaken to understand the mechanism of chromium action in

New high-performance liquid chromatographic method for the detection of picolinic acid in biological fluids.

C Dazzi et al.

Journal of chromatography. B, Biomedical sciences and applications, 751(1), 61-68 (2001-03-10)

A HPLC method is described to quantify picolinic acid in milk, blood serum and tissue culture supernatant. The method requires very little sample preparation because acid precipitation allows total recovery of picolinic acid. High specificity and sensitivity were obtained using

Orient. J. Chem., 9, 60-60 (1993)

High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients.

Yasuhide Miyoshi et al.

BMC cancer, 14, 717-717 (2014-09-27)

There is currently no consensus on the correlations between androgen concentrations in prostate tissue and blood and stage and pathological grade of prostate cancer. In this study, we used a newly-developed ultra-sensitive liquid-chromatography tandem mass spectrometry method to measure testosterone

Lanthanide complexes based on a diazapyridinophane platform containing picolinate pendants.

Adrián Roca-Sabio et al.

Inorganic chemistry, 51(20), 10893-10903 (2012-09-29)

A new macrocyclic ligand, N,N'-bis[(6-carboxy-2-pyridyl)methyl]-2,11-diaza[3.3](2,6)pyridinophane (H(2)BPDPA), was prepared, and its coordination properties toward the Ln(III) ions were investigated. The hydration numbers (q) obtained from luminescence lifetime measurements in aqueous solution of the Eu(III) and Tb(III) complexes indicate that they contain

Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: spectral characterization, cyclic voltammetric investigations and crystal structure.

Zafar A Siddiqi et al.

European journal of medicinal chemistry, 57, 102-111 (2012-10-11)

Complexes of stoichiometries [M(oda)(4-pic)H(2)O]·xH(2)O [M = Cu(1), x = 2; Co (2), x = 4; Ni (3), x = 2; ] [Fe(oda)(4-pic)]·Cl (4) and {[Cu(2-pa)(2)]·2H(2)O}(n) (5) (H(2)oda = oxydiacetic acid, 4-pic = 4-picoline and 2-paH = 2-picolinic acid) were prepared

Anti-atherogenic effect of chromium picolinate in streptozotocin-induced experimental diabetes.

Bhuvaneshwari Sundaram et al.

Journal of diabetes, 5(1), 43-50 (2012-06-02)

Several studies have implicated changes in the levels of trace elements in diabetes. Chromium is one such element that seems to potentiate insulin action, thereby regulating carbohydrate and lipid metabolism. The aim of the present study was to evaluate the

Oligomerization of 2-chloroallyl alcohol by 2-pyridinecarboxylate complex of chromium(III) - new highly active and selective catalyst.

Joanna Drzeżdżon et al.

Scientific reports, 8(1), 8632-8632 (2018-06-07)

The new 2-pyridinecarboxylate (2-pic) complex of chromium(III) has been designed and synthesized as a new highly active and selective oligomerization catalyst. The crystal structure of the new compound has been determined by X-ray diffraction. The composition and purity of [Cr(2-pic)2(OH2)2]NO3

Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.

Wenjun Zhou et al.

Brain, behavior, and immunity, 46, 147-153 (2015-02-01)

Chronic pain frequently co-occurs with major depressive disorder but the mechanisms are poorly understood. We investigated the contribution of indoleamine 2,3-dioxygenase-1 (IDO1), a rate-limiting enzyme in the conversion of tryptophan to neurotoxic metabolites, to this comorbidity using the spared nerve

M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.

Antje Blumenthal et al.

PloS one, 7(5), e37314-e37314 (2012-06-01)

Indoleamine 2,3-dioxygenesae-1 (IDO-1) catalyses the initial, rate-limiting step in tryptophan metabolism, thereby regulating tryptophan availability and the formation of downstream metabolites, including picolinic and quinolinic acid. We found that Mycobacterium tuberculosis infection induced marked upregulation of IDO-1 expression in both

Hepatoprotective activity of CrPic against alloxan-induced hepatotoxicity in mice.

Weijiang Fan et al.

Biological trace element research, 149(2), 227-233 (2012-04-25)

This study focused on oxidation hepatic injury induced by alloxan treatment in mice and the hepatoprotective effect of chromium picolinate (CrPic) against such injury. The mice were randomly divided into three groups (control, alloxan, and CrPic). The CrPic mice were

Transition Met. Chem. (London), 19, 521-521 (1994)

Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin.

Kazim Sahin et al.

The British journal of nutrition, 110(2), 197-205 (2012-12-06)

The objective of the present study was to evaluate anti-diabetic effects of chromium picolinate (CrPic) and biotin supplementations in type 2 diabetic rats. The type 2 diabetic rat model was induced by high-fat diet (HFD) and low-dose streptozotocin. The rats

Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis.

Elizabeth W Chia et al.

Bioorganic & medicinal chemistry, 16(21), 9432-9442 (2008-10-07)

Sixteen new thiazine-quinoline-quinones have been synthesised, plus one bicyclic analogue. These compounds inhibited neutrophil superoxide production in vitro with IC(50)s as low 60 nM. Compounds with high in vitro anti-inflammatory activity were also tested in a mouse model of acute

Interaction of vanadium(IV) with human serum apo-transferrin.

Sameena Mehtab et al.

Journal of inorganic biochemistry, 121, 187-195 (2013-02-16)

The interaction of V(IV)O-salts as well as of a few V(IV)O(carrier)n complexes with human serum transferrin (hTF) is studied focusing on the determination of the nature and stoichiometry of the binding of V(IV)O(2+) to hTF, as well as whether the

Picolinic acid, a catabolite of tryptophan, as the second signal in the activation of IFN-gamma-primed macrophages.

L Varesio et al.

Journal of immunology (Baltimore, Md. : 1950), 145(12), 4265-4271 (1990-12-15)

We have studied the effects of picolinic acid, a product of tryptophan degradation, on the activation of mouse peritoneal macrophages (M phi). Picolinic acid acts synergistically with IFN-gamma in activating M phi from C57BL/6 mice. Moreover, M phi from C3H/HeJ

Orient. J. Chem., 9, 43-43 (1993)

A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats.

Nurhan Sahin et al.

Nutritional neuroscience, 15(5), 42-47 (2012-12-13)

A novel nutritional supplement complex (N21 #125) composed of four well-known compounds (chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron) was designed to improve memory function and maintain brain health. The present study evaluated the complex's potential mechanism of action and

Simultaneous voltammetric analysis of tryptophan and kynurenine in culture medium from human cancer cells.

Ilona Sadok et al.

Talanta, 209, 120574-120574 (2020-01-02)

The paper outlines the first report of application of a differential pulse voltammetry for simultaneous quantification of clinically important molecular markers - tryptophan and its metabolite - kynurenine. The analytes were determined in less than 60 s at the boron-doped diamond electrode

The efficacy of chromium as a growth enhancer for mirror carp (Cyprinus carpio L): an integrated study using biochemical, genetic, and histological responses.

Arafat R Ahmed et al.

Biological trace element research, 148(2), 187-197 (2012-02-22)

A growth trial was conducted on juvenile mirror carp (Cyprinus carpio L.) for 8 weeks to compare the efficacy of three chromium (Cr) compounds (Cr chloride, Cr picolinate, and Cr yeast) at a level 0.5 mg/kg as a potential growth

Improved profiling of estrogen metabolites by orbitrap LC/MS.

Xingnan Li et al.

Steroids, 99(Pt A), 84-90 (2014-12-30)

Estrogen metabolites are important biomarkers to evaluate cancer risks and metabolic diseases. Due to their low physiological levels, a sensitive and accurate method is required, especially for the quantitation of unconjugated forms of endogenous steroids and their metabolites in humans.

Metabolic stability of new anticonvulsants in body fluids and organ homogenates.

Dorota Marszałek et al.

Acta poloniae pharmaceutica, 69(1), 47-51 (2012-05-12)

The stability as a function of time of compounds with established anticonvulsant activity: picolinic acid benzylamide (Pic-BZA), picolinic acid 2-fluorobenzylamide (Pic-2-F-BZA), picolinic acid 3-fluorobenzylamide (Pic-3-F-BZA), picolinic acid 4-fluorobenzylamide (Pic-4-F-BZA) and picolinic acid 2-methylbenzylamide (Pic-2-Me-BZA) in body fluids and homogenates of

Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics.

Kristina Yeghiazaryan et al.

Infectious disorders drug targets, 12(5), 332-339 (2012-09-29)

Nephropathy is the leading secondary complication of metabolic syndrome. Nutritional supplement by chromium-picolinate is assumed to have renoprotective effects. However, potential toxic effects reported increase the concerns about the safety of chromium-picolinate. The experimental design aimed at determining, whether the

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Arun Sreekumar et al.

Nature, 457(7231), 910-914 (2009-02-13)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

Jennifer A Jacobsen et al.

Journal of medicinal chemistry, 54(2), 591-602 (2010-12-30)

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metalloproteases

Picolinic acid in acrodermatitis enteropathica: evidence for a disorder of tryptophan metabolism.

I Krieger et al.

Journal of pediatric gastroenterology and nutrition, 3(1), 62-68 (1984-01-01)

Three children with acrodermatitis enteropathica (AE) were treated with oral zinc dipicolinate (zinc-PA). The daily dose of zinc required to prevent exacerbations, when administered as the dipicolinate complex, was one-third the minimum amount of zinc required as the sulfate salt.

Self-assembled hybrid metal oxide base catalysts prepared by simply mixing with organic modifiers.

Masazumi Tamura et al.

Nature communications, 6, 8580-8580 (2015-10-06)

Multidentate materials formed by simply mixing heterogeneous and homogeneous components are promising for construction of versatile active sites on the surface of heterogeneous compounds, however, to the best of our knowledge, there are no reports on such materials. Self-assembly of

Chromium picolinate attenuates hyperglycemia-induced oxidative stress in streptozotocin-induced diabetic rats.

Bhuvaneshwari Sundaram et al.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 27(2), 117-121 (2012-11-06)

Chromium picolinate is advocated as an anti-diabetic agent for impaired glycemic control. It is a transition metal that exists in various oxidation states and may thereby act as a pro-oxidant. The present study has been designed to examine the effect

Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: mechanism for formation of the 2,2'-bipyridyl ring.

Ignacio Garcia et al.

Chemistry & biology, 19(3), 399-413 (2012-03-27)

The gene cluster for the bipyridyl compound collismycin was characterized from Streptomyces sp. CS40. Sequence analysis of a 46.7 kb DNA region revealed 27 open reading frames, 23 of which are involved in collismycin biosynthesis. Eight insertional inactivation mutants were

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