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Showing 1-30 of 209 results for "S2532" within Papers
Takeshi K Matsui et al.
Neuroscience letters, 670, 75-82 (2018-02-06)
Recently, researchers have developed protocols for human cerebral organoids using human pluripotent stem cells, which mimic the structure of the developing human brain. Existing research demonstrated that human cerebral organoids which undergo short cultivation periods, contain astrocytes, neurons, and neural
Erin-Mai F Lim et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(9), E1707-E1716 (2017-02-01)
AlphaB-crystallin (αBC) is a small heat shock protein that is constitutively expressed by peripheral nervous system (PNS) axons and Schwann cells. To determine what role this crystallin plays after peripheral nerve damage, we found that loss of αBC impaired remyelination
Satoru Matsuda et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(36), 12543-12557 (2012-09-08)
Despite the importance of the production of new neurons in the adult hippocampus, the transcription network governing this process remains poorly understood. The High Mobility Group (HMG)-box transcription factor, Sox2, and the cell surface activated transcriptional regulator, Notch, play important
Aurélie Delzor et al.
Human gene therapy methods, 23(4), 242-254 (2012-09-01)
Tissue-targeted expression is of major interest for studying the contribution of cellular subpopulations to neurodegenerative diseases. However, in vivo methods to investigate this issue are limited. Here, we report an analysis of the cell specificity of expression of fluorescent reporter
Eric Wildon Kostuk et al.
Glia, 67(8), 1542-1557 (2019-04-27)
Parkinson's disease (PD) is characterized by the selective degeneration of dopamine (DA) neurons of the substantia nigra pars compacta (SN), while the neighboring ventral tegmental area (VTA) is relatively spared. The mechanisms underlying this selectivity are not fully understood. Here
Seongjun Park et al.
Scientific reports, 5, 9669-9669 (2015-05-20)
Due to the limited regenerative ability of neural tissue, a diverse set of biochemical and biophysical cues for increasing nerve growth has been investigated, including neurotrophic factors, topography, and electrical stimulation. In this report, we explore optogenetic control of neurite
Nobuhiro Kurabayashi et al.
EMBO reports, 16(11), 1548-1562 (2015-09-17)
Down syndrome (DS) arises from triplication of genes on human chromosome 21 and is associated with anomalies in brain development such as reduced production of neurons and increased generation of astrocytes. Here, we show that differentiation of cortical progenitor cells
Manganese taken up into the CNS via the olfactory pathway in rats affects astrocytes.
Henriksson J and Tjalve H
Toxicological Sciences, 55(2), 392-398 (2000)
Brashket Seth et al.
The Journal of biological chemistry, 292(47), 19423-19440 (2017-10-07)
The widely used carbamate pesticide carbofuran causes neurophysiological and neurobehavioral deficits in rodents and humans and therefore poses serious health hazards around the world. Previously, we reported that gestational carbofuran exposure has detrimental effects on hippocampal neurogenesis, the generation of
Tamara Tanos et al.
PloS one, 12(7), e0181151-e0181151 (2017-07-19)
The olfactory mucosa (OM) has the unique characteristic of performing an almost continuous and lifelong neurogenesis in response to external injuries, due to the presence of olfactory stem cells that guarantee the maintenance of the olfactory function. The easy accessibility
Federica Verginelli et al.
Nature communications, 4, 2956-2956 (2013-12-21)
Glioblastoma (GBM) is the most common and deadly malignant brain cancer, with a median survival of <2 years. GBM displays a cellular complexity that includes brain tumour-initiating cells (BTICs), which are considered as potential key targets for GBM therapies. Here
Serum levels of S100B protein and neuron-specific enolase are associated with mortality in critically ill patient.
Duda I, et al.
Acta Biochimica Polonica, 64(4) (2017)
Yan Wang et al.
Journal of the neurological sciences, 232(1-2), 59-63 (2005-04-27)
ABCA2, which belongs to the A subclass of the ATP-binding cassette (ABC) transporter superfamily, is predominantly expressed in the cytoplasm of oligodendrocytes and Schwann cells, the myelin-forming cells in brain and peripheral nerve, respectively. Here, we demonstrate by immunoblot and
Jinar Rostami et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(49), 11835-11853 (2017-11-02)
Many lines of evidence suggest that the Parkinson's disease (PD)-related protein α-synuclein (α-SYN) can propagate from cell to cell in a prion-like manner. However, the cellular mechanisms behind the spreading remain elusive. Here, we show that human astrocytes derived from
Y-H Tsai et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 23(4), 362-369 (2011-01-05)
Identification of neuronal progenitor/stem cells in the postnatal gut suggests the development of transplantation approaches to enteric nervous system (ENS) diseases. Many clinical applications would require engrafting large segments of postnatal gut in vivo. We investigated the ability of unselected
TORC1-dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice.
Abs E et al
Annals of Neurology, 74(4), 569-579 (2013)
Bianka Brunne et al.
Glia, 58(13), 1553-1569 (2010-06-16)
The dentate gyrus is a brain region where neurons are continuously born throughout life. In the adult, the role of its radial glia in neurogenesis has attracted much attention over the past years; however, little is known about the generation
Barbara Gellén et al.
Journal of proteomics, 153, 53-64 (2016-07-03)
Neonatal rodents chronically treated with the tricyclic antidepressant clomipramine show depression-like behavior, which persists throughout adulthood. Therefore, this animal model is suitable to investigate the pathomechanism of depression, which is still largely unknown at the molecular level beyond monoaminergic dysfunctions.
C J Janmaat et al.
PloS one, 10(12), e0145235-e0145235 (2015-12-19)
In stem cell cultures from adult human tissue, undesirable contamination with fibroblasts is frequently present. The presence of fibroblasts obscures the actual number of stem cells and may result in extracellular matrix production after transplantation. Identification of fibroblasts is difficult
The immunohistochemical characterization of human fetal olfactory bulb and olfactory ensheathing cells in culture as a source for clinical CNS restoration.
Liu, K., et al.
The Anatomical Record, 293, 359-369 (2010)
Bin Shen et al.
Theranostics, 7(11), 2794-2805 (2017-08-22)
The ability to locate nerve injury and ensuing neuroinflammation would have tremendous clinical value for improving both the diagnosis and subsequent management of patients suffering from pain, weakness, and other neurologic phenomena associated with peripheral nerve injury. Although several non-invasive
Jeffrey T Cole et al.
Frontiers in neuroanatomy, 6, 18-18 (2012-06-02)
In the brain, metabolism of the essential branched chain amino acids (BCAAs) leucine, isoleucine, and valine, is regulated in part by protein synthesis requirements. Excess BCAAs are catabolized or excreted. The first step in BCAA catabolism is catalyzed by the
Boaz Barak et al.
Nature neuroscience, 22(5), 700-708 (2019-04-24)
Williams syndrome (WS), caused by a heterozygous microdeletion on chromosome 7q11.23, is a neurodevelopmental disorder characterized by hypersociability and neurocognitive abnormalities. Of the deleted genes, general transcription factor IIi (Gtf2i) has been linked to hypersociability in WS, although the underlying
Amanda M Gleixner et al.
Molecular neurobiology, 53(7), 4939-4960 (2015-09-17)
Astrocytes are one of the major cell types to combat cellular stress and protect neighboring neurons from injury. In order to fulfill this important role, astrocytes must sense and respond to toxic stimuli, perhaps including stimuli that are severely stressful
Moe Matsuo et al.
American journal of physiology. Lung cellular and molecular physiology, 304(11), L736-L745 (2013-03-26)
The airway is covered by multicilia that beat in a metachronous manner toward the mouth to eliminate debris and infectious particles. Coordinated one-directional beating is an essential feature of multicilia in the airway to guarantee proper mucociliary clearance. Defects in
Yukari Shigemoto-Mogami et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(6), 2231-2243 (2014-02-07)
Although microglia have long been considered as brain resident immune cells, increasing evidence suggests that they also have physiological roles in the development of the normal CNS. In this study, we found large numbers of activated microglia in the forebrain
S100β as a serum marker in endocrine resistant breast cancer.
Charmsaz S, et al.
BMC Medicine, 15(1), 79-79 (2017)
Astrid Zayas-Santiago et al.
PloS one, 9(5), e97155-e97155 (2014-05-17)
Müller cells, the principal glial cells of the vertebrate retina, are fundamental for the maintenance and function of neuronal cells. In most vertebrates, including humans, Müller cells abundantly express Kir4.1 inwardly rectifying potassium channels responsible for hyperpolarized membrane potential and
Robert Beattie et al.
Neuron, 94(3), 517-533 (2017-05-05)
The concerted production of neurons and glia by neural stem cells (NSCs) is essential for neural circuit assembly. In the developing cerebral cortex, radial glia progenitors (RGPs) generate nearly all neocortical neurons and certain glia lineages. RGP proliferation behavior shows
Catherine-Alexandra Grégoire et al.
PloS one, 9(1), e86237-e86237 (2014-01-28)
Environmental enrichment (EE) exerts powerful effects on brain physiology, and is widely used as an experimental and therapeutic tool. Typical EE paradigms are multifactorial, incorporating elements of physical exercise, environmental complexity, social interactions and stress, however the specific contributions of
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