SHC201

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Showing 1-10 of 10 results for "SHC201" within Papers

Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia.

Cuellar TL, et al.

The Journal of Cell Biology (2017)

SENP2 suppresses NF-κB activation and sensitizes breast cancer cells to doxorubicin.

Xiaoyu Gao et al.

European journal of pharmacology, 854, 179-186 (2019-04-04)

Doxorubicin is a chemotherapeutic agent commonly used to treat breast cancer. However, breast cancer often develops drug resistance, leading to disease recurrence and poor prognosis. Delineating the mechanisms underlying drug resistance is imperative for overcoming the challenge of treating doxorubicin-resistant

ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation.

Dakota L Jones et al.

The Journal of cell biology, 220(5) (2021-02-25)

Matrix stiffness is a central regulator of fibroblast function. However, the transcriptional mechanisms linking matrix stiffness to changes in fibroblast phenotype are incompletely understood. Here, we evaluated the effect of matrix stiffness on genome-wide chromatin accessibility in freshly isolated lung

A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.

Dompe N, et al.

PLoS ONE, 13(6), e0199264-e0199264 (2018)

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice.

Janet Lau et al.

Nature communications, 8, 14572-14572 (2017-02-22)

Expression of PD-L1, the ligand for T-cell inhibitory receptor PD-1, is one key immunosuppressive mechanism by which cancer avoids eradication by the immune system. Therapeutic use of blocking antibodies to PD-L1 or its receptor PD-1 has produced unparalleled, durable clinical

Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element.

J E Donello et al.

Journal of virology, 72(6), 5085-5092 (1998-05-30)

The hepatitis B virus posttranscriptional regulatory element (HBVPRE) is a cis-acting RNA element that partially overlaps with enhancer I and is required for the cytoplasmic accumulation of HBV surface RNAs. We find that the closely related woodchuck hepatitis virus (WHV)

Activated Wnt/β-Catenin signaling contributes to E3 ubiquitin ligase EDD-conferred docetaxel resistance in prostate cancer.

Pan Bian et al.

Life sciences, 254, 116816-116816 (2019-09-01)

Docetaxel is commonly used to treat hormone-refractory prostate cancer (HRPC), but its clinical efficacy is limited by drug resistance, with the molecular mechanisms remaining elusive. The E3 ubiquitin ligase EDD modifies substrate proteins through ubiquitination and is involved in the

Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer.

Shruthi Sriramkumar et al.

Molecular cancer research : MCR, 18(11), 1699-1710 (2020-08-18)

Platinum resistance is a common occurrence in high-grade serous ovarian cancer and a major cause of ovarian cancer deaths. Platinum agents form DNA cross-links, which activate nucleotide excision repair (NER), Fanconi anemia, and homologous recombination repair (HRR) pathways. Chromatin modifications

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

R Zufferey et al.

Journal of virology, 73(4), 2886-2892 (1999-03-12)

The expression of genes delivered by retroviral vectors is often inefficient, a potential obstacle for their widespread use in human gene therapy. Here, we explored the possibility that the posttranscriptional regulatory element of woodchuck hepatitis virus (WPRE) might help resolve

Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs.

Sahu N, et al.

Nature Communications, 7, 12351-12351 (2016)

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