162957
6-羟基多巴胺 氢溴酸盐
95% (HPLC), powder, neurotoxin
别名:
2-（2，4，5-三羟基苯基）乙胺 氢溴酸盐, 2，4，5-三羟基苯乙胺 氢溴酸盐, 2，5-二羟基酪胺 氢溴酸盐, 6 -羟基多巴胺
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关于此项目
线性分子式:
(HO)3C6H2CH2CH2NH2 · HBr
化学文摘社编号:
分子量:
250.09
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
211-247-0
MDL number:
Beilstein/REAXYS Number:
3713280
产品名称
6-羟基多巴胺 氢溴酸盐, 95%
Quality Level
assay
95%
form
powder
mp
216-220 °C (lit.)
storage temp.
−20°C
SMILES string
Br.NCCc1cc(O)c(O)cc1O
InChI
1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChI key
MLACDGUOKDOLGC-UHFFFAOYSA-N
General description
溶液应新鲜制备，并且应避光。
Application
6-羟基多巴胺合溴化氢可用于：
- 诱导小鼠模型中的帕金森病（PD）以研究tubastatin A （TBA）对SH-SY5Y细胞中核苷酸结合寡聚化结构域和富亮氨酸重复Pyrin 3序列结构域（NLRP3） 以及细胞损伤的作用。
- 诱导交感神经的药理学消融以研究肝交感神经活性（SNA）对食源性肥胖小鼠中肝脂肪变性的作用
- 诱导中脑细胞中的氧化应激以研究其对腹侧中脑的神经元细胞中p75NTR 信号传递的作用。
Biochem/physiol Actions
6-羟基多巴胺合溴化氢（6-OHDA）是一种神经毒素，可诱导氧化损伤并破坏含儿茶酚胺或交感神经末梢。它常用于诱发实验模型中的帕金森′病。6-OHDA可通过产生活性氧物质，引发细胞应激和细胞死亡而发挥细胞毒性。
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ppe
dust mask type N95 (US), Eyeshields, Gloves
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
Woori Kim et al.
Neurobiology of aging, 35(7), 1712-1721 (2014-02-25)
Dopamine (DA) neurons in sporadic Parkinson's disease (PD) display dysregulated gene expression networks and signaling pathways that are implicated in PD pathogenesis. Micro (mi)RNAs are regulators of gene expression, which could be involved in neurodegenerative diseases. We determined the miRNA
C C Real et al.
Neuroscience, 237, 118-129 (2013-02-12)
Physical exercise is known to produce beneficial effects to the nervous system. In most cases, brain-derived neurotrophic factor (BDNF) is involved in such effects. However, little is known on the role of BDNF in exercise-related effects on Parkinson's disease (PD).
Yun-Qi Xu et al.
CNS neuroscience & therapeutics, 19(3), 170-177 (2013-01-03)
In addition to their original applications for lowering cholesterol, statins display multiple neuroprotective effects. Inflammatory reactions and the PI3K/AKT/caspase 3 pathway are strongly implicated in dopaminergic neuronal death in Parkinson's disease (PD). This study aims to investigate how simvastatin affects
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 162957-1G | 04061838747266 |
| 162957-250MG | 04061838747273 |
| 162957-50MG | 04061838747280 |
| 162957-5G | 04061833505229 |