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文件

244929

乙二胺氯化铂(II)

Name: 乙二胺氯化铂(II)
Brand: ALDRICH

99%

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别名:

二氯化乙二胺铂, 二氯（1,2-乙二胺）铂, 二氯（1,2-二氨基乙烷）铂

线性分子式:

(H₂NCH₂CH₂NH₂)PtCl₂

CAS号:

14096-51-6

分子量:

326.08

EC 号:

237-943-4

MDL编号:

MFCD00000011

PubChem化学物质编号:

24854717

NACRES:

NA.22

检测方案

99%

形式

solid

reaction suitability

core: platinum
reagent type: catalyst

SMILES string

Cl[Pt]Cl.NCCN

InChI

1S/C2H8N2.2ClH.Pt/c3-1-2-4;;;/h1-4H2;2*1H;/q;;;+2/p-2

InChI key

LMABILRJNNFCPG-UHFFFAOYSA-L

象形图

GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

预防措施声明

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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T1503

货号

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Modulation of platinum antitumor drug binding to DNA by linked and free intercalators.

B E Bowler et al.

Biochemistry, 25(10), 3031-3038 (1986-05-20)

We report the DNA binding site preferences of the novel molecule AO-Pt, in which the anticancer drug dichloro(ethylenediamine)platinum(II) is linked by a hexamethylene chain to acridine orange. The sequence specificity of platinum binding was mapped by exonuclease III digestion of

Steric control of stereoselective interactions between the platinum(II) complex [PtCl2(1,4-diazacycloheptane)] and DNA: comparison with cis-[PtCl2(NH3)2] and [PtCl2(ethane-1,2-diamine)] using DNA binding and molecular modeling studies.

T W Hambley et al.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 6(5-6), 534-542 (2001-07-27)

The rate and extent of binding of [PtCl2(hpip)] (hpip=homopiperazine-1,4-diazacycloheptane) and cis-[PtCl2(NH3)2] to calf thymus DNA was measured using atomic absorption spectroscopy and it was found that [PtCl2(hpip)] bound both more rapidly and to a greater extent than did cis-[PtCl2(NH3)2]. The

Coordination chemistry in biological media: reactions of antitumor Pt(II) and Au(III) complexes with cell culture media.

J D Bell et al.

Journal of inorganic biochemistry, 31(4), 241-246 (1987-12-01)

Reactions of cis-PtCl2(NH3)2 (1), Pt(1,2-diaminoethane)Cl2 (2), PtCl4(2-) (3), and AuCl4- (4) with intact cell culture media have been studied by spin-echo 500 MHz proton NMR spectroscopy. This has allowed us to observe reactions of components of the media at submillimolar

Cross-linking of glutathione to DNA by cancer chemotherapeutic platinum coordination complexes.

A Eastman

Chemico-biological interactions, 61(3), 241-248 (1987-03-01)

Glutathione can modulate the toxicity of a variety of drugs, although its role in modulating toxicity by anticancer platinum drugs is ambivalent. At physiologically relevant concentrations, glutathione can inhibit the reaction between DNA and cis-dichloro(ethylenediamine)platinum(II) (cis-DEP). Glutathione can also react

[Antiviral action of the macromolecular derivative of the platinum with deoxyribonucleic acid in the treatment of patient with malignant liver neoplasm].

S A Shalimov et al.

Klinicheskaia khirurgiia, (8)(8), 36-38 (1994-01-01)

Results of the action of a preparation consisting of cis-dichlorodiammineplatinum and deoxyribonucleic acid combined in the saline balanced solution by means of the original technique on cytomegalovirus infection of patients with cancer of the liver are presented. Clearly pronounced antivirus

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