Merck
CN

409537

Sigma-Aldrich

聚(乙二醇)甲基丙烯酸酯

average Mn 360, contains 500-800 ppm MEHQ as inhibitor

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别名:
PEGMA, 乙氧化甲基丙烯酸2-羟乙酯, 聚氧乙烯单甲基丙烯酸酯
线性分子式:
H2C=C(CH3)CO(OCH2CH2)nOH
CAS号:
MDL编号:
NACRES:
NA.23

形式

liquid

分子量

average Mn 360

包含

500-800 ppm MEHQ as inhibitor

反应适用性

reagent type: cross-linking reagent
reaction type: Polymerization Reactions

折射率

n20/D 1.464

密度

1.105 g/mL at 25 °C

Ω端

hydroxyl

α端

methacrylate

聚合物结构设计

shape: linear
functionality: heterobifunctional

InChI

1S/C6H10O3/c1-5(2)6(8)9-4-3-7/h7H,1,3-4H2,2H3

InChI key

WOBHKFSMXKNTIM-UHFFFAOYSA-N

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一般描述

聚乙二醇(PEG)是适合生物应用的材料,因为它不会触发免疫反应。它可以通过乙撑氧阴离子环和一系列末端基团(比如基丙烯酸甲酯:PEGMA)开环聚合来合成。PEG是一种亲水聚合物,当交联成网状时,可以形成水凝胶。丙烯酸酯和甲基丙烯酸酯链末端经过链聚合形成PEGMA水凝胶。

应用

PEGMA 可以作为单体合成:
  • 可降解微球,采用悬浮聚合工艺。PEGMA 的两亲性允许在水悬浮过程中通过直接油进行聚合。
  • 用于有效去除水中重金属的聚合螯合微珠。
也可通过 Michael 加成反应合成微颗粒或纳米颗粒基壳聚糖/聚乙二醇复合材料。PEGMA 接枝提高了壳聚糖在水介质中的溶解度。这些颗粒可作为眼科给药系统的载体。

外形

官能化单甲基丙烯酸酯

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Skin Irrit. 2

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

235.4 °F - closed cup

闪点(°C)

113 °C - closed cup

个人防护装备

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Mir Mukkaram Ali;
Macromolecules, 37, 5219-5227 (2004)
Biofouling-resistance expanded poly (tetrafluoroethylene) membrane with a hydrogel-like layer of surface-immobilized poly (ethylene glycol) methacrylate for human plasma protein repulsions.
Chang Y, et al.
Journal of Membrane Science, 323(1), 77-84 (2008)

商品

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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