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关于此项目
经验公式(希尔记法):
C34H40N4O7S
化学文摘社编号:
分子量:
648.77
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
8302671
Quality Level
assay
≥98.0% (HPLC)
form
powder or crystals
optical activity
[α]/D -5.5±1.0°, c = 1 in DMF
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
−20°C
SMILES string
Cc1c(C)c(c(C)c2CC(C)(C)Oc12)S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)OCC3c4ccccc4-c5ccccc35)C(O)=O
InChI
1S/C34H40N4O7S/c1-19-20(2)30(21(3)26-17-34(4,5)45-29(19)26)46(42,43)38-32(35)36-16-10-15-28(31(39)40)37-33(41)44-18-27-24-13-8-6-11-22(24)23-12-7-9-14-25(23)27/h6-9,11-14,27-28H,10,15-18H2,1-5H3,(H,37,41)(H,39,40)(H3,35,36,38)/t28-/m0/s1
InChI key
HNICLNKVURBTKV-NDEPHWFRSA-N
General description
Fmoc-Arg(Pbf)-OH被用于肽合成的合成嵌段,为特定官能团提供保护,同时高效形成肽键。
Application
Fmoc-Arg(Pbf)-OH是Fmoc保护的氨基酸衍生物,可用于制备含精氨酸的肽。2,2,4,6,7-五甲基二氢苯并呋喃-5-磺酰基(Pbf)易于被三氟乙酸(TFA)裂解。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Solid phase synthesis, radiolabeling and biological evaluation of a 99mTc-labeled αVβ3 tripeptide (RGD) conjugated to DOTA as a tumor imaging agent.
Varshney R, et al.
Cancer Biology & Therapy, 11(10), 893-901 (2011)
The 2, 2, 4, 6, 7-pentamethyldihydrobenzofuran-5-sulfonyl group (Pbf) as arginine side chain protectant.
Carpino L A, et al.
Tetrahedron Letters, 34(49), 7829-7832 (1993)
Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.
Tamamura H, et al.
Organic & Biomolecular Chemistry, 1(21), 3663-3669 (2003)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 47349-25G | 04061832360928 |
| 47349-100G | 04061832360911 |
| 47349-1KG | 04061826222461 |
| 47349-5G | 04061832360935 |