聚乙二醇甲基醚

Accumulation of biological matter at surfaces is an inevitable event in virtually any environment in which natural and man-made materials are used. Although sometimes fouling of surfaces with biomolecules and bioorganisms has little consequence, biofouling must be minimized or controlled in order to maintain performance and safety of devices and structures.

Fouling Resistant Biomimetic Poly(Ethylene Glycol) Based Grafted Polymer Coatings

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.