86734
1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸
≥97.0% (CHN)
别名:
DOTA
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关于此项目
经验公式（希尔记法）:
C16H28N4O8 · xH2O
化学文摘社编号:
分子量:
404.42 (anhydrous basis)
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1186987
Assay:
≥97.0% (CHN)
Form:
powder
Quality Level
assay
≥97.0% (CHN)
form
powder
functional group
carboxylic acid
SMILES string
OC(=O)CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O
InChI
1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)
InChI key
WDLRUFUQRNWCPK-UHFFFAOYSA-N
Application
1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)是一种大环络合剂。
- 它已用于通过螯合64Cu放射性同位素进行碳纳米管生物偶联物的放射性标记。
- DOTA可被N-羟基琥珀酰亚胺基活化，进而与单克隆抗体偶联，用于临床放射免疫治疗。
- 它可与钆形成配合物用作MRI造影剂。
- DOTA肽偶联物的金属配合物可用作治疗用放射性药物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The aim of this work was to investigate the use of 13 C-labelled acetoacetate and β-hydroxybutyrate as novel hyperpolarized substrates in the study of cardiac metabolism. [1-13 C]Acetoacetate was synthesized by catalysed hydrolysis, and both it and [1-13 C]β-hydroxybutyrate were
Javad Garousi et al.
Scientific reports, 7(1), 5961-5961 (2017-07-22)
Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer therapy. The
Luca Garbuio et al.
The journal of physical chemistry. B, 117(11), 3145-3153 (2013-02-28)
We present the first example of chemoselective site-specific spin labeling of a monomeric protein with two spectroscopically orthogonal spin labels: a gadolinium(III) chelate complex and a nitroxide radical. A detailed analysis of the performance of two commercially available Gd(III) ligands
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 86734-250MG | 04061833282250 |
| 86734-50MG | 04061833041758 |