908525
Poly(D,L-lactide-b-glycolide) lactide:glycolide 75:25
amine (dihydrazide) terminated, average Mn 12,000
别名:
Amino-PLGA, Amino-functionalized PLGA, AminoPLGA, NH2 PLGA, PLGA-NH2
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线性分子式:
C2H7N2(C3H4O2)x(C2H2O2)yH
NACRES:
NA.23
UNSPSC Code:
12162002
form
powder or chunks
feed ratio
lactide:glycolide 75:25
mol wt
average Mn 12,000
color
white to tan
storage temp.
−20°C
Application
Biocompatible and biodegradable polymer can be used in the formation of nanoparticles for drug delivery. The amine functional group on the chain end enables rapid and facile surface functionalization, allowing for this material to be used in applications such as targeted drug delivery.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact