926248
Redox Responsive Poly(ethylene glycol)-block-poly(lactide-alt-glycolide)
PEG average Mn 5000, PLGA Mn 15000
别名:
Drug release, PEG-PLGA with disulfide linkage, PEG-SS-PLGA, Stimuli-responsive
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关于此项目
线性分子式:
CH3O(C2H4O)nC7H12O4S2(C5H6O4)m
UNSPSC Code:
12352112
NACRES:
NA.23
form
powder, chunks or granules
Quality Level
mol wt
PEG average Mn 5000, PLGA Mn 15000
storage temp.
2-8°C
SMILES string
O=C(C(C)OC(CO[H])=O)OCCSSCCOC(OCCOCCOC)=O
InChI
1S/C15H26O10S2/c1-12(25-13(17)11-16)14(18)22-7-9-26-27-10-8-24-15(19)23-6-5-21-4-3-20-2/h12,16H,3-11H2,1-2H3
InChI key
DPMVWUUTGXWXPV-UHFFFAOYSA-N
Application
PEG-SS-PLGA is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(lactide-alternative-glycolide) (PLGA) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.
Different from common Poly(lactide-co-glycolide) (PLGA) polymer, the lactic and glycolic units in Poly(lactide-alt-glycolide) block alternate in sequence in the polymer chain, and the molar ratio of lactic to glycolic units in the polymer is exactly 1:1.
Poly(lactide-alt-glycolide) exhibits excellent solubility in common organic solvents, such as acetonitrile, acetone, dioxane, DCM, and THF, providing great convenience for drug delivery researches and applications.
Different from common Poly(lactide-co-glycolide) (PLGA) polymer, the lactic and glycolic units in Poly(lactide-alt-glycolide) block alternate in sequence in the polymer chain, and the molar ratio of lactic to glycolic units in the polymer is exactly 1:1.
Poly(lactide-alt-glycolide) exhibits excellent solubility in common organic solvents, such as acetonitrile, acetone, dioxane, DCM, and THF, providing great convenience for drug delivery researches and applications.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.
Lin Yu et al.
Biomacromolecules, 12(4), 1290-1297 (2011-03-03)
This paper reports the influence of sequence structures of block copolymers composed of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) on their thermogelling aqueous behaviors. A series of thermogelling PLGA-PEG-PLGA triblock copolymers with similar chemical compositions and block lengths
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 926248-1G | 04065267918204 |