description
3β-hydroxy-5,24-cholestadiene
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (700060P-10mg), pkg of 1 × 5 mg (700060P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCC=C(C)C)C)(CC3)C)CC=C2C1)C
InChI
1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
AVSXSVCZWQODGV-DPAQBDIFSA-N
General description
与胆固醇相比，链甾醇缺少C24和C25之间的双键。它存在于精细胞和星形胶质细胞的细胞膜中，也是大脑主要固醇。
Application
链甾醇已作为甾醇用于测试与人类蛋白质Mincle的相互作用，并作为内部标准品用于超高效液相色谱-串联质谱(UHPLC-MS/MS)。它可以用于制备脂单层。
Biochem/physiol Actions
链甾醇是Bloch途径中的胆固醇前体，24-去氢胆固醇还原酶在此步骤中起催化作用。链甾醇在24-去氢胆固醇还原酶的损耗过程中累积，导致链甾醇化。链甾醇是肝X受体(LXR)激动剂。它是治疗神经退行性疾病的潜在靶点。链甾醇可调节巨噬细胞中的炎症信号。
Packaging
5 mL 棕色玻璃螺旋盖小瓶 (700060P-10 mg)
5 mL 棕色玻璃螺旋盖小瓶 (700060P-5 mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
María de Las Mercedes Carro et al.
Biochimica et biophysica acta. Biomembranes, 1862(9), 183357-183357 (2020-05-18)
Ram sperm are particularly sensitive to freeze-thawing mainly due to their lipid composition, limiting their use in artificial insemination programs. We evaluated the extent of cholesterol and desmosterol incorporation into ram sperm through incubation with increasing concentrations of methyl-β-cyclodextrin (MβCD)-sterol
Saara Vainio et al.
The Journal of biological chemistry, 281(1), 348-355 (2005-10-27)
Desmosterol is an immediate precursor of cholesterol in the Bloch pathway of sterol synthesis and an abundant membrane lipid in specific cell types. The significance of the difference between the two sterols, an additional double bond at position C24 in
Guangtao Li et al.
Journal of lipid research, 61(5), 758-766 (2020-01-23)
The formation and properties of liquid-ordered (Lo) lipid domains (rafts) in the plasma membrane are still poorly understood. This limits our ability to manipulate ordered lipid domain-dependent biological functions. Giant plasma membrane vesicles (GPMVs) undergo large-scale phase separations into coexisting
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 700060P-5MG | 04061835384693 |
| 700060P-10MG | 04061835384686 |