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Merck
CN

05-168

Anti-TNFα Antibody, clone MPG-XT3

clone MPG-XT3, Upstate®, from rat

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
MPG-XT3, monoclonal
Application:
Neutral
Citations:
13
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biological source

rat

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MPG-XT3, monoclonal

species reactivity

mouse

manufacturer/tradename

Upstate®

technique(s)

neutralization: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... TNF(7124)

General description

17 kDa
The concentration of antibody needed to neutralize the bioactivity of TNF-α will depend on the cell type, the incubation conditions, and the biological response studied.

Immunogen

Recombinant murine TNF-α

Application

Research Category
Signaling
Research Sub Category
Growth Factors & Receptors
This Anti-TNFalpha Antibody, clone MPG-XT3 is validated for use in NEUT for the detection of TNFα.

Biochem/physiol Actions

mouse TNF-α; does not recognize human or rat TNF-α

Physical form

0.01M Tris-glycine, 0.15M NaCl, pH 7.4
DEAE chromatography
Format: Purified

Preparation Note

2 years at -20°C

Analysis Note

routinely used to neutralize 50% of the cytotoxic effect of recombinant mouse TNF-α on actinomycin D treated L929 cells.

Other Notes

Replaces: 04-1114

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii.
Hunter, C A, et al.
Infection and Immunity, 61, 4038-4044 (1993)
TNF-alpha is the critical mediator of the cyclic AMP-induced apoptosis of CD8+4+ double-positive thymocytes.
Guevara Pati??o, et al.
Journal of Immunology, 164, 1689-1694 (2019)
C K Yu et al.
International archives of allergy and immunology, 112(1), 73-82 (1997-01-01)
Dermatophagoides farinae (Der f) is one of the most common species of dust mites that induce asthma and allergic rhinitis. We have reported that Der f challenge on sensitized mice elicited a distinct type of hypersensitivity, called early-type hypersensitivity (ETH)



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货号GTIN
05-16804053252672323