biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
99D, monoclonal
species reactivity
rat, human, mouse
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... BIN1(274)
mouse ... Bin1(30948)
General description
56kDa
Immunogen
对应于人 Bin1氨基酸 189-398的部分融合蛋白 克隆99D
Application
研究类别
细胞凋亡 & 癌症
细胞凋亡 & 癌症
研究子类别
BCL2 & 抑制
BCL2 & 抑制
抗-Bin1抗体(克隆99D)是用于IP、WB、 IH.的抗-Bin1 抗体。
Biochem/physiol Actions
Bin1
Physical form
0.1M Tris-甘氨酸,pH 7.4,含0.05%叠氮化钠
形式:纯化
蛋白G色谱
Preparation Note
在-20°C下保存1年
Analysis Note
通过免疫印迹对C2C12细胞的RIPA裂解液进行了常规评估
Other Notes
替代:MAB4131
由于许可协议限制,无法购买该产品进行转售。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Suppression of MEK/ERK signalling by Myc: role of Bin-1.
Telfer, JF; Urquhart, J; Crouch, DH
Cellular Signalling null
R Wechsler-Reya et al.
Cancer research, 57(15), 3258-3263 (1997-08-01)
BIN1 is a putative tumor suppressor that was identified in a genetic screen for polypeptides that interact with the MYC oncoprotein. Using a set of six monoclonal antibodies, we identified and examined biochemical features and localization of cellular BIN1. Epitope
Maxime Sartori et al.
Acta neuropathologica, 138(4), 631-652 (2019-05-09)
The bridging integrator 1 gene (BIN1) is a major genetic risk factor for Alzheimer's disease (AD). In this report, we investigated how BIN1-dependent pathophysiological processes might be associated with Tau. We first generated a cohort of control and transgenic mice