主要文件

查看所有文档

349254

NS-398

Name: NS-398
Brand: MM

A cell-permeable selective inhibitor of COX-2 in vitro.

别名:

NS-398, N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₁₃H₁₈N₂O₅S

化学文摘社编号:

123653-11-2

分子量:

314.36

UNSPSC Code:

41121800

NACRES:

NA.77

MDL number:

MFCD00882995

Assay:

≥98% (TLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Level

100

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

pale yellow

solubility

DMSO: 20 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

[S](=O)(=O)(Nc1c(cc(cc1)[N+](=O)[O-])OC2CCCCC2)C

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

InChI key

KTDZCOWXCWUPEO-UHFFFAOYSA-N

说明

General description

A cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC₅₀ = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.

A cell-permeable, selective inhibitor of cyclooxygenase-2 (COX-2) in vitro. Inhibits sheep placenta COX-2 (IC₅₀ = 3.8 µM) while COX-1 activity is completely unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations of 0.3 to 5 mg/kg. Does not produce any significant gastrointestinal lesions even at single oral doses of 1000 mg/kg. A useful tool to explore the role of COX-2 in physiologic and pathophysiologic processes.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
COX-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 3.8 µM against COX-2

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Ouellet, M., and Percival, M.D. 1995. Biochem. J.306, 247.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol.81, 259.
Futaki, N., et al. 1993. Gen. Pharmacol.24, 105.
Futaki, N., et al. 1993. J. Pharm.Pharmacol.45, 753.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Still not finding the right product?

Explore all of our products under

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c