420097
Janus蛋白酪氨酸激酶(JAK)抑制剂I
≥98% (HPLC), liquid
别名:
InSolution JAK抑制剂I, 2-（1，1-二甲基乙基）-9-氟-3，6-二氢-7H-苯并[h]-咪唑[4，5-f]异喹啉-7-酮，P6，吡啶酮6，DBI，JAK1抑制剂I，JAK2抑制剂I，JAK3抑制剂X
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C18H16FN3O
化学文摘社编号:
分子量:
309.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
产品名称
Janus蛋白酪氨酸激酶(JAK)抑制剂I, InSolution, ≥98%
Quality Level
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
2-8°C
SMILES string
Fc1cc2c(c3[nH]c(nc3c4c2c(ncc4)O)C(C)(C)C)cc1
InChI
1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
InChI key
VNDWQCSOSCCWIP-UHFFFAOYSA-N
General description
Janus蛋白酪氨酸激酶（JAKs）的有效抑制剂。显示对JAK1（对于鼠JAK1，IC50=15 nM）、JAK2（IC50=1 nM）、JAK3（Ki=5 nM）和Tyk2（IC50=1 nM）的有效抑制活性。它仅在高得多的浓度下抑制其他激酶。还抑制CTLL细胞的IL-2和IL-4依赖性增殖，并阻断STAT5的磷酸化。
Biochem/physiol Actions
5 nM，针对JAK3
主要靶标
鼠JAK1
鼠JAK1
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：分别针对鼠JAK1和JAK2的15 nM，1 nM；针对Tyk2为1 nM
Packaging
用惰性气体包装
Physical form
10 mM（500 µg/162 µl）JAK抑制剂I（目录号420099）的DMSO溶液。
Preparation Note
初次使用后，等分并冷藏（4°C）。
Other Notes
Thompson, J.E., et al. 2002.Bioorg.Med. Chem. Lett.12, 1219.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
Still not finding the right product?
Explore all of our products under Janus蛋白酪氨酸激酶(JAK)抑制剂I
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
Kathryn G V Anderson et al.
Nature cell biology, 19(10), 1164-1177 (2017-09-26)
Signalling downstream of Activin/Nodal (ActA) and Wnt can induce endoderm differentiation and also support self-renewal in pluripotent cells. Here we find that these apparently contradictory activities are fine-tuned by insulin. In the absence of insulin, the combination of these cytokines
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 420097-500UG | 04055977187861 |