476485
PKA Inhibitor 14-22 Amide
≥95% (HPLC), PKA Inhibitor, lyophilized
别名:
PKA抑制剂14-22酰胺，细胞可渗透，豆蔻酰化
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关于此项目
经验公式（希尔记法）:
C53H100N20O12
分子量:
1209.49
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
lyophilized
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
产品名称
PKA抑制剂14-22酰胺，细胞可渗透，豆蔻酰化, PKA Inhibitor 14-22 Amide is myristoylated at the N-terminus that enhances its cell-permeability. The non-myristoylated version is shown to be a specific inhibitor of PKA (Ki = 36 nM).
Quality Level
assay
≥95% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
热稳定的蛋白激酶抑制剂（PKI）肽序列（14-22），在N端已被肉豆蔻酰化，增强了其细胞通透性。该肽的非肉豆蔻酰化形式是cAMP依赖性蛋白激酶（PKA）的高度特异性抑制剂（Ki=36 nM）。
Biochem/physiol Actions
主要靶标
cAMP依赖性蛋白激酶
cAMP依赖性蛋白激酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标Ki：36 nMf或cAMP依赖性蛋白激酶
Physical form
作为三氟乙酸盐提供。
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Other Notes
Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
Paman, K., et al. 1998.J. Lipid Res. 39, 1091.
Rimon, G., and Rubin M. 1998.Biochim.Biophys.Acta 1380, 289.
Harris, T.E., et al. 1997.Biochem.Biophys.Res. Commun.232, 648.
Muniz, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 14461.
Zoukhri, D., et al. 1997.Am. J. Physiol.272, C263.
Eichholtz, T., et al. 1993.J. Biol. Chem.268, 1982.
Ward, N.E. and O’Brian, C.A.1993.Biochemistry32, 11903.
Walsh, D.A. and Glass, D.B.1991.Methods Enzymol.201, 304.
Glass, D.B., et al. 1989.J. Biol. Chem.264, 8802.
Rimon, G., and Rubin M. 1998.Biochim.Biophys.Acta 1380, 289.
Harris, T.E., et al. 1997.Biochem.Biophys.Res. Commun.232, 648.
Muniz, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 14461.
Zoukhri, D., et al. 1997.Am. J. Physiol.272, C263.
Eichholtz, T., et al. 1993.J. Biol. Chem.268, 1982.
Ward, N.E. and O’Brian, C.A.1993.Biochemistry32, 11903.
Walsh, D.A. and Glass, D.B.1991.Methods Enzymol.201, 304.
Glass, D.B., et al. 1989.J. Biol. Chem.264, 8802.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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The Journal of physiology, 598(14), 2847-2873 (2019-02-17)
Small-conductance Ca2+ -activated K+ (SK) channels expressed in ventricular myocytes are dormant in health, yet become functional in cardiac disease. SK channels are voltage independent and their gating is controlled by intracellular [Ca2+ ] in a biphasic manner. Submicromolar [Ca2+
Yanyong Xu et al.
Nature metabolism, 3(1), 59-74 (2021-01-20)
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 476485-500UG | 04055977183832 |