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安全信息

5.00111

SAFC

Cocarboxylase tetrahydrate

(thiamine pyrophosphate tetrahydrate), EMPROVE® API

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别名:
Cocarboxylase tetrahydrate
经验公式（希尔记法）:
C12H18N4O7P2S · 4H2O
CAS号:
68684-55-9
分子量:
496.37
EC索引号:
205-230-7

质量水平

600

产品线

EMPROVE® API

形式

solid

pH值（酸碱度）

2.4-3.2 (20 °C, 100 g/L in H2O)

溶解性

55 g/L

堆积密度

450 kg/m3

应用

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

储存温度

2-25°C

InChI

1S/C12H18N4O7P2S.4H2O/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;;;;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);4*1H2

InChI key

KLOLNRGPRQYTIW-UHFFFAOYSA-N

一般描述

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

Cocarboxylase tetrahydrate Emprove® API is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Cocarboxylase Tetrahydrate (thiamine diphosphoric acid ester tetrahydrate) Emprove® API is manufactured according to ICH Q7 guidelines. An ASMF is available.

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

The substance 5.00111 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Ferenc Tóth et al.
Bone, 132, 115214-115214 (2019-12-31)
Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor-β superfamily, it is known to be a factor involved in skeletal development and capable of inducing in vitro osteogenic differentiation of mesenchymal stem cells (MSCs). Dental pulp

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