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516485

Pepstatin A Methyl Ester

Name: Pepstatin A Methyl Ester
Brand: MM

A cell-permeable methyl ester derivative of Pepstatin A that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase.

别名:

Pepstatin A Methyl Ester, Isovaleryl-V V-Sta-A-Sta-OCH₃, PME

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关于此项目

经验公式（希尔记法）:

C₃₅H₆₅N₅O₉

分子量:

699.92

NACRES:

NA.77

UNSPSC Code:

12352108

Assay:

≥95% (HPLC)

Form:

lyophilized

Quality level:

100

Storage condition:

OK to freeze

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属性

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

solubility

DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

说明

General description

A cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516481) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (K_is = 150 nM, K_ii = 320 nM in solubilized human γ-secretase at 20°C; K_is is the inhibition constant for inhibitor binding to the free enzyme and K_ii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex). Sta = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
γ-secretase

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Other Notes

Tian, G., et al. 2002. J. Biol. Chem.277, 31499.
Zhang, L., et al. 2001. Biochemistry40, 5049.
Murphy, M.P., et al. 1999. J. Biol. Chem.274, 11914.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c