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553211

雷帕霉素

Name: 雷帕霉素
Brand: MM

≥95% (HPLC), solution, mTOR inhibitor, Calbiochem

别名:

InSolution雷帕霉素, mTOR抑制剂I

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关于此项目

经验公式（希尔记法）:

C₅₁H₇₉NO₁₃

分子量:

914.17

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solution

Quality level:

100

Storage condition:

desiccated (hygroscopic), protect from light

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属性

产品名称

雷帕霉素, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

Quality Level

100

assay

≥95% (HPLC)

form

solution

manufacturer/tradename

Calbiochem^®

storage condition

desiccated (hygroscopic), protect from light

shipped in

wet ice

storage temp.

−20°C

说明

General description

选择性抑制 p70 S6 激酶的磷酸化和激活（IC₅₀ = 50 pM）。防止 IGF-II 的翻译激活。还防止静止的 T 细胞进入细胞周期，但不直接阻止细胞周期进程。研究表明，可抑制随后的信号传导事件，例如 p110Rb 磷酸化、p34cdc2 激酶激活和细胞周期蛋白 A 合成。表现出与 FK-50 6结合蛋白的强结合力。还据报道在鼠 B 细胞系中诱导凋亡，抑制淋巴因子诱导的细胞增殖（在 G₁ 期），并不可逆地阻滞酿酒酵母细胞（在 G₁ 期）。

Biochem/physiol Actions

主靶
雷帕霉素（mTOR）的哺乳动物靶标

产物不与ATP竞争。

可逆：否

细胞渗透性：否

靶标IC₅₀：50 pM 抑制雷帕霉素（mTOR）的哺乳动物靶标，并阻断随后的 p70 S6 激酶的激活

Packaging

用惰性气体包装

Physical form

在DMSO中的溶液浓度为2.5 mg/mL（2.74 mM）

Preparation Note

初次使用后，等分并冷冻（-20°C）。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：刺激性（B）

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

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全球贸易项目编号

货号	GTIN
553211-500UG	04055977193558
553211-1MG	04055977193541