8.51221
PyAOP
for peptide synthesis, Novabiochem®
别名:
PyAOP, (7-Azabenzotriazol-1-yloxy)trispyrrolidinophosphonium hexafluorophosphate
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关于此项目
经验公式（希尔记法）:
C17H27F6N7OP2
化学文摘社编号:
分子量:
521.38
UNSPSC Code:
12352101
NACRES:
NA.22
MDL number:
产品名称
PyAOP, Novabiochem®
Quality Level
product line
Novabiochem®
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
-10 to -25°C
SMILES string
F[P-](F)(F)(F)(F)F.[P](=[N+]5CCCC5)(N4CCCC4)(N3CCCC3)O[n]1nnc2c1nccc2
InChI
1S/C17H27N7OP.F6P/c1-2-11-21(10-1)26(22-12-3-4-13-22,23-14-5-6-15-23)25-24-17-16(19-20-24)8-7-9-18-17;1-7(2,3,4,5)6/h7-9H,1-6,10-15H2;/q+1;-1
InChI key
CBZAHNDHLWAZQC-UHFFFAOYSA-N
General description
PyAOP is an extremely effective coupling reagent that mediates amide bond formation with the efficiency of HATU but without the risk of guanidine formation, making it the reagent of choice for peptide cyclization.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references:
[1] F. Albericio, et al. (1997) Tetrahedron Lett., 38, 4853.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references:
[1] F. Albericio, et al. (1997) Tetrahedron Lett., 38, 4853.
Application
PyAOP can be used as a coupling reagent:
- In the synthesis of N,N′-substituted acylguanidines by solid-phase peptide synthesis.
- To facilitate the formation of peptide bonds during the synthesis of cyclic peptide hybrids.
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
hcodes
flash_point_f
No data available
flash_point_c
No data available
商品
Novabiochem®可提供大量的偶联剂用于原位活化。原位活化试剂易于使用 - 即使是利用空间位阻氨基酸，并且它们的使用通常没有副反应。
Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 8512210025 | 04027269684969 |
| 8512210100 | 04027269684976 |