biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
General description
凋亡受包含分子和蛋白酶的胱天蛋白酶家族的死亡结构域(DD)和/或胱天蛋白酶募集结构域(CARD)调节。 含有细胞死亡调节剂的CARD包括RAIDD,RICK,Bcl10,Apaf-1,ARC,胱天蛋白酶-2和胱天蛋白酶-9。 已经在人和小鼠中鉴别出含有蛋白的新型CARD结构域,并将其命名为ASC和TMS1。 ASC/TMS1的异位表达通过激活胱天蛋白酶-9诱导凋亡并抑制人乳腺癌细胞的存活。 ASC/TMS1的过表达诱导DNA断裂。 ASC/TMS1在多种人类和小鼠组织中表达。
Immunogen
对应于人ASC的aa 182-195(RESQSYLVEDLERS)的肽。
Application
蛋白质印迹:1:500
HL60全细胞裂解液可作为阳性对照。
最佳工作稀释度必须由最终用户进行确定。
HL60全细胞裂解液可作为阳性对照。
最佳工作稀释度必须由最终用户进行确定。
研究子类别
凋亡-附加
凋亡-附加
研究类别
细胞凋亡 & 癌症
细胞凋亡 & 癌症
该抗ASC抗体经过验证可用于WB检测ASC。
Biochem/physiol Actions
通过蛋白质印迹检测对应于ASC/TMS1的25 kDa条带。
Physical form
亲和纯化的免疫球蛋白。 含0.02%叠氮化钠的PBS液体。
形式:纯化
Preparation Note
在4°C下可保存长达6个月。
Other Notes
浓度:请参考批次特异性浓缩物的分析证书。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
存储类别
12 - Non Combustible Liquids
Jie Zhao et al.
Journal of Crohn's & colitis, 15(4), 647-664 (2020-10-07)
Crohn's disease [CD] is a chronic, relapsing and incurable inflammatory disorder. Micro RNAs [miRNAs], which modulate gene expression by binding to mRNAs, may make significant contributions to understanding the complex pathobiology and aetiology of CD. This study aimed to investigate
Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes.
Bryan NB, Dorfleutner A, Kramer SJ, Yun C, Rojanasakul Y, Stehlik C
Journal of Inflammation (London, England) null
Y Xing et al.
Cell death & disease, 7(8), e2322-e2322 (2016-08-05)
Autophagosomes derived from tumor cells, also referred to as defective ribosomal products in blebs (DRibbles), have been previously shown to stimulate potent T-cell responses and mediate tumor regression when used as therapeutic cancer vaccines in multiple preclinical cancer models. In
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| AB3607 | 04053252284588 |