ABC213
抗磷酸化ULK1 抗体（Ser777）
from rabbit, purified by affinity chromatography
别名:
Serine/threonine-protein kinase ULK1, Serine/threonine-protein kinase Unc51.1, Unc-51-like kinase 1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
human
Application:
WB, inhibition assay
Citations:
3
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
inhibition assay: suitable (peptide), western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pSer777)
General description
ULK1或自噬相关蛋白1同源物（ATG1）是丝氨酸/苏氨酸蛋白激酶。它是一种普遍表达的蛋白，在大脑，骨骼肌和心脏中非常丰富。它参与mTOR受体的信号通路，导致营养缺乏细胞中自噬的调节。mTOR可以作为ULK1/FIP200/Atg13的复合物与ULK1相互作用。ULK1可能在神经元发育中起重要作用：通过靶向断裂ULK1s的激酶结构域来消除ULK1′s的酶活性，可能通过阻断ULK1介导的神经营养因子的运输来阻止发育中的小鼠大脑中神经元的生长。
观察值〜120 kDa
Immunogen
KLH偶联线性肽，对应于Ser1177磷酸化的人ULK1的C末端附近区域。
Application
抗磷酸化ULK1抗体（Ser777）是一种高度特异性的兔多克隆抗体，靶向自噬相关蛋白，&已在蛋白质印迹&肽抑制分析中测试。
通过蛋白质印迹/肽抑制分析在A431细胞裂解液中进行了评估。
蛋白质印迹/肽抑制分析：2 µg/mL的该抗体在10 µg A431细胞裂解物中检测到磷酸化ULK1（Ser777）。
蛋白质印迹/肽抑制分析：2 µg/mL的该抗体在10 µg A431细胞裂解物中检测到磷酸化ULK1（Ser777）。
Analysis Note
通过蛋白质印迹在A431细胞裂解物中进行了评估。
蛋白质印迹分析：2 µg/mL的该抗体在10 µg A431细胞裂解物中检测到磷酸化ULK1（Ser777）。
蛋白质印迹分析：2 µg/mL的该抗体在10 µg A431细胞裂解物中检测到磷酸化ULK1（Ser777）。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| ABC213 | 04053252941191 |