产品名称
抗-亨廷顿蛋白抗体,a.a.1-82, ascites fluid, clone 2B4, Chemicon®
biological source
mouse
Quality Level
antibody form
ascites fluid
antibody product type
primary antibodies
clone
2B4, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... HTT(3064), SLC6A4(6532)
General description
348 kDa
Immunogen
表位:a.a.1-82
重组人亨廷顿蛋白,氨基酸1-82。
Application
抗-亨廷顿蛋白抗体,a.a.1-82是用于ELISA、IC、IH&WB的抗亨廷顿蛋白的抗体。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
蛋白质印迹:1:500-1:5,000
免疫细胞化学(1): 1:500-1:5,000
免疫组织化学(1,2): 1:500-1:5000
ELISA:1:500-1:5,000
最佳工作稀释度必须由最终用户确定。
免疫细胞化学(1): 1:500-1:5,000
免疫组织化学(1,2): 1:500-1:5000
ELISA:1:500-1:5,000
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
与亨廷顿蛋白(氨基酸1-82)反应。该抗体可识别野生型和突变型亨廷顿蛋白。
Physical form
不含防腐剂的腹水。
未纯化
Preparation Note
自收到之日起在-20°C可稳定保存1年。分装保存以避免反复冻融。为了最大程度地回收产品,需在融化后和取下盖子之前将原始样品管进行离心。
Analysis Note
对照
正常人大脑皮层裂解物,来自HD或野生型小鼠的小鼠大脑皮层样品
正常人大脑皮层裂解物,来自HD或野生型小鼠的小鼠大脑皮层样品
Other Notes
浓度:关于批次特定浓度请参见检验报告。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明,否则我们的产品预期仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Acetylation targets mutant huntingtin to autophagosomes for degradation.
Hyunkyung Jeong,Florian Then,Thomas J Melia,Joseph R Mazzulli,Libin Cui,Jeffrey N Savas et al.
Cell null
Xiaofeng Gu et al.
Neuron, 85(4), 726-741 (2015-02-11)
The nucleus is a critical subcellular compartment for the pathogenesis of polyglutamine disorders, including Huntington's disease (HD). Recent studies suggest the first 17-amino-acid domain (N17) of mutant huntingtin (mHTT) mediates its nuclear exclusion in cultured cells. Here, we test whether
Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.
Bin Huang, Johannes Schiefer, Christian Sass, Christoph M Kosinski, Stefan Kochanek
The journal of gene medicine null
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MAB5492 | 04053252576782 |