MABF111
抗-MIF抗体，克隆M1，不含防腐剂
clone M1, from mouse
别名:
Macrophage migration inhibitory factor, MIF, Glycosylation-inhibiting factor, GIF, L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
M1, monoclonal
Species reactivity:
human
Application:
FACS, Neutral, WB
Citations:
3
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
M1, monoclonal
species reactivity
human
technique(s)
flow cytometry: suitable, neutralization: suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
glycosylation
Gene Information
human ... MIF(4282)
General description
MIF（也称巨噬细胞迁移抑制因子或糖基化抑制因子（GIF）、L-多巴色素异构酶、L-多巴色素互变异构酶或苯丙酮酸互变异构酶）由MIF/GLIF/MMIF基因编码，它是一种促炎细胞因子，与机体对细菌性病原体的固有免疫应答有关。巨噬细胞在受到细菌脂多糖或细菌抗原刺激时分泌MIF，MIF在发炎位置的表达表明它作为中介在宿主防御中有调节巨噬细胞功能的作用。MIF也阻止糖皮质激素的抗炎活性，并具有多种酶活性，但是它们的生理功能是未知的。MIF主要在淋巴细胞、巨噬细胞和免疫系统细胞中表达。MIF的缺陷可能与全身性幼年型类风湿关节炎有关，这种疾病是一种从16岁开始出现的全身性炎症性关节病。在严重脓毒病病例中MIF 的血清水平升高，并与低生存率有关。
计算分子量为12 kDa
Immunogen
对应于人MIF的重组蛋白。
Application
中和试验分析：一个来自独立实验室的代表性批次在人外周血粒细胞的迁移过程中检测到 MIF（Rupreht, R. R., et al. (2000).Pflugers Arch.440(5 Suppl):R78-80）。
该抗MIF抗体（克隆 M1，不含防腐剂）经验证可用于流式细胞术、中和&蛋白质印迹检测MIF。
Physical form
形式：纯化
Analysis Note
通过流式细胞术对Jurkat细胞进行了评估。
流式细胞术：1 µg的该抗体在1X10E6 Jurkat 细胞中检测到MIF。
流式细胞术：1 µg的该抗体在1X10E6 Jurkat 细胞中检测到MIF。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Ravi Kumar et al.
PloS one, 12(6), e0179012-e0179012 (2017-07-01)
Glioblastoma is the most common primary tumor of the brain and has few long-term survivors. The local and systemic immunosuppressive environment created by glioblastoma allows it to evade immunosurveillance. Myeloid-derived suppressor cells (MDSCs) are a critical component of this immunosuppression.
R R Rupreht et al.
Pflugers Archiv : European journal of physiology, 440(5 Suppl), R78-R80 (2000-09-27)
Macrophage Migration Inhibitory Factor (MIF) is a crucial component of the immune system acting together with glucocorticosteroids to regulate immunity and inflammation. Understanding of its many putative functions and action mechanisms is still ambiguous. Due to the newest findings that
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MABF111 | 04053252943225 |