MABF33
抗-MHC II类（I-A/I-E）抗体，克隆M5/114
clone M5/114, from rat
别名:
CD74 molecule, major histocompatibility complex, class II invariant chain, Ia-associated invariant chain, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), gamma chain of class II antigens, Ia antigen-
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
M5/114, monoclonal
Application:
FACS, IHC, WB
Citations:
5
biological source
rat
Quality Level
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
M5/114, monoclonal
species reactivity
mouse
technique(s)
flow cytometry: suitable, immunohistochemistry: suitable, western blot: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Cd74(16149)
General description
MHC II类相关不变量链（I-A/I-E），也称Ia抗原相关不变量链，是含有单个甲状腺球蛋白I型结构域的单通道II型膜糖蛋白。它们是MHC II类抗原处理过程中的关键组成部分，在α / β异二聚体合成后形成稳定复合物，并协调复合物从发生II类肽装载的ER区转移。
观测值〜32 kDa。
选择性剪接产生2种亚型：32 kDa（长亚型）和 24 kDa（短亚型）。
选择性剪接产生2种亚型：32 kDa（长亚型）和 24 kDa（短亚型）。
Application
使用经验证可用于WB、FC、IH的该抗-MHC II类（I-A/I-E）抗体，克隆M5/114检测MHC II类（I-A/I-E）。
流式细胞分析：先前批次已被独立实验室用于脾细胞FC。（Bhattacharya, A., et al. (1981). The Journal of immunology.127(6):2488-2496。）
免疫组织化学分析：先前批次已被独立实验室用于胸腺组织IH。(de Bont, E., et al. (1999). Int. Immunol. 11(8):1295-1306.）
免疫组织化学分析：先前批次已被独立实验室用于胸腺组织IH。(de Bont, E., et al. (1999). Int. Immunol. 11(8):1295-1306.）
Physical form
形式：纯化
Analysis Note
已通过蛋白质印迹在小鼠脾组织裂解液中进行了评估。
蛋白质印迹分析：1 µg/mL该抗体在10 µg小鼠脾组织裂解液中检测到MHC II类（I-A/I-E）。
蛋白质印迹分析：1 µg/mL该抗体在10 µg小鼠脾组织裂解液中检测到MHC II类（I-A/I-E）。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism.
Deleon-Pennell, KY; de Castro Bras, LE; Lindsey, ML
Physiological Reports null
Madison Bolger-Munro et al.
eLife, 8 (2019-06-04)
When B cells encounter antigens on the surface of an antigen-presenting cell (APC), B cell receptors (BCRs) are gathered into microclusters that recruit signaling enzymes. These microclusters then move centripetally and coalesce into the central supramolecular activation cluster of an
Jia C Wang et al.
Journal of cell science, 130(6), 1094-1109 (2017-02-09)
B cells that bind antigens displayed on antigen-presenting cells (APCs) form an immune synapse, a polarized cellular structure that optimizes the dual functions of the B cell receptor (BCR), signal transduction and antigen internalization. Immune synapse formation involves polarization of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MABF33 | 04053252413872 |