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PHR1043

泼尼松龙

Name: 泼尼松龙
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

1,4-孕甾二烯-11β,17α,21-三醇-3,20-二酮, 1-去氢氢化可的松, 1-去氢皮质醇, 11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₈O₅

化学文摘社编号:

50-24-8

分子量:

360.44

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823073

EC Number:

200-021-7

Beilstein/REAXYS Number:

1354103

MDL number:

MFCD00003649

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. P2700000, traceable to USP 1555005

API family

prednisolone

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

240 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

OIGNJSKKLXVSLS-VWUMJDOOSA-N

Gene Information

human ... NR3C1(2908)

说明

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Prednisolone is a glucocorticoid utilized as an anti-inflammatory or an immunosuppressive drug.

Application

Prednisolone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Prednisolone may be used as a standard in the separation and determination of prednisolone in serum samples of animals using radioimmunoassay.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA6903 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS08

signalword

Danger

hcodes

H360FD

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

法规信息

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Development and validation of spectrophotometric and HPLC method for the simultaneous estimation of salbutamol sulphate and prednisolone in tablet dosage form

Chitlange SS, et al.

Journal of Analytical and Bioanalytical Techniques, 2(117), 2-2 (2011)

Separation of serum prednisolone and prednisolone-21-hemisuccinate by extraction and their concurrent determination by radioimmunoassay

Yanaglbashl, K, et al.

Clinical Chemistry, 26(9), 1301-1303 (1980)

Quantitative determination of captopril and prednisolone in tablets by FT-Raman spectroscopy

Mazurek S and Szostak R

Journal of Pharmaceutical and Biomedical Analysis, 40(5), 1225-1230 (2006)

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全球贸易项目编号

货号	GTIN
PHR1043-500MG	04061835237135