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C0166000

骨化二醇

Name: 骨化二醇
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

25-羟基维生素D₃ 一水合物, 25-羟基胆钙化醇

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关于此项目

经验公式（希尔记法）:

C₂₇H₄₄O₂ · H₂O

化学文摘社编号:

63283-36-3

分子量:

418.65

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329774765

MDL number:

MFCD00867077

Beilstein/REAXYS Number:

4270041

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属性

biological source

sheep wool (grease)

grade

pharmaceutical primary standard

agency

API family

calcifediol

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CCCC(C)(C)O

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

InChI key

JWUBBDSIWDLEOM-DTOXIADCSA-N

Gene Information

human ... VDR(7421)

说明

General description

本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需更多信息和支持，请访问现行药典的网站。骨化二醇是维生素 D 的一种生物活性代谢物。由于对维生素D结合蛋白的高亲和力，与麦角钙化醇或胆钙化醇相比，它更具强的亲水性和更好的肠道吸收。众所周知该药物可治疗与肠道吸收减少和肥胖相关的疾病。

Application

骨化二醇EP 参考标准品设计用于欧洲药典规定的实验室测试。

Packaging

本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。

Other Notes

可能适用相应的销售限制。

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301 + H311,H330,H372

pcodes

P260 - P264 - P280 - P302 + P352 + P312 - P304 + P340 + P310 - P314

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Hypovitaminosis D: is it time to consider the use of calcifediol?

Cesareo R, et al.

Nutrients, 11(5), 1016-1016 (2019)

Serum sclerostin in high-activity adult patients with juvenile idiopathic arthritis.

Kristyna Brabnikova-Maresova et al.

Arthritis research & therapy, 16(5), 460-460 (2014-10-05)

Juvenile idiopathic arthritis (JIA) is a disease associated with loss of bone mass, deterioration in bone mass quality and an increased risk of fractures. The objective of this study was to evaluate factors that predict bone mineral density (BMD) alterations

Modified-release calcifediol effectively controls secondary hyperparathyroidism associated with vitamin D insufficiency in chronic kidney disease.

Stuart M Sprague et al.

American journal of nephrology, 40(6), 535-545 (2015-01-13)

Vitamin D insufficiency drives secondary hyperparathyroidism (SHPT) and is associated with increased cardiovascular mortality in patients with chronic kidney disease (CKD). SHPT is poorly addressed by current vitamin D repletion options. The present study evaluated a novel investigational vitamin D

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货号	GTIN
C0166000	04061833799529