Quality Level
grade
certified reference material, pharmaceutical secondary standard
agency
USP 1397006
API family
methacycline
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
-10 to -25°C
SMILES string
Cl[H].[H][C@@]12[C@@H](O)[C@]3([H])C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
InChI
1S/C22H22N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-6,10,14-15,17,25,27-29,32H,1H2,2-3H3,(H2,23,31);1H/t10-,14-,15+,17+,22+;/m1./s1
InChI key
VZQARNDJLLWXGL-CCHMMTNSSA-N
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Methacycline hydrochloride is one of the tetracycline antibiotics effective against a broad-spectrum of Gram-positive and Gram-negative bacteria. It is formed as an intermediate during the preparation of oxytetracycline. Its antibacterial activity is higher than that of tetracycline and oxytetracycline. It finds applications in human and veterinary medications as well as feed additives.
Application
Methacycline hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and electroanalytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2077 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Methacycline hydrochloride
USP42-NF37
United States Pharmacopeia/National Formulary (2013)
Ion selective PVC membrane electrode for the determination of methacycline hydrochloride in pharmaceutical formulation
Aboul-Enein H, et al.
Sensors, 2(10), 424-431 (2002)
Rapid liquid chromatographic method for simultaneous determination of tetracyclines antibiotics and 6-Epi-doxycycline in pharmaceutical products using porous graphitic carbon column
Monser L and Darghouth F
Journal of Pharmaceutical and Biomedical Analysis, 23(2-3), 353-362 (2000)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| PHR1594-1G | 04061834431589 |