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PHR1796

亚胺培南

Name: 亚胺培南
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

亚胺培南一水合物, Primaxin 一水合物, Tienam 一水合物, （5R，6S）-6-[（（1R）-1-羟基乙基] -3-[[2-[（亚氨基甲基）氨基]乙基]硫代] -7-氧代-1-氮杂双环[3.2.0] hept-2 -烯-2-羧酸一水合物

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₇N₃O₄S · H₂O

化学文摘社编号:

74431-23-5

分子量:

317.36

NACRES:

NA.24

PubChem Substance ID:

329823620

UNSPSC Code:

41116107

EC Number:

264-734-5

MDL number:

MFCD09753321

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. I0090000, traceable to USP 1337809

API family

imipenem

form

solid

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

storage temp.

-10 to -25°C

SMILES string

O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O

InChI

1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1

InChI key

GSOSVVULSKVSLQ-JJVRHELESA-N

说明

General description

药物二级标准品CRM，为制药行业QC实验室及生产质量控制和研发，提供了一种方便、高性价比且符合相关法规的替代方案。亚胺培南(imipenem)属于碳青霉烯类物质，是一种β-内酰胺类抗生素，对需氧和厌氧菌具有抗菌作用。碳青霉烯(Carbapenem)抑制细菌细胞壁形成中的肽聚糖合成，从而导致目标菌的死亡。

Application

亚胺培南可作为药物参考标准品，通过各种分析技术测定生物样本和药物制剂中的分析物。

Biochem/physiol Actions

亚胺培南一水合物是广谱 B -内酰胺抗生素。

亚胺培南一水合物是广谱 B -内酰胺抗生素。它是碳青霉烯类“魔弹”抗生素的一种，用于严重感染。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

欲查看此物质的分析证书样本，请在下面的对话框中输入 LRAC0262。这只是一个示例证书，可能与您收到的批次不符。

该认证参考物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

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分析证书(COA)

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Insights into the Periplasmic Proteins of Acinetobacter baumannii AB5075 and the Impact of Imipenem Exposure: A Proteomic Approach.

Daniela Scribano et al.

International journal of molecular sciences, 20(14) (2019-07-25)

Carbapenem-resistant Acinetobacter baumannii strains cause life-threatening infections due to the lack of therapeutic options. Although the main mechanisms underlying antibiotic-resistance have been extensively studied, the general response to maintain bacterial viability under antibiotic exposure deserves to be fully investigated. Since

Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae.

Tae Hwan Kim et al.

mBio, 11(1) (2020-02-13)

Poor penetration through the outer membrane (OM) of Gram-negative bacteria is a major barrier of antibiotic development. While β-lactam antibiotics are commonly used against Klebsiella pneumoniae and Enterobacter cloacae, there are limited data on OM permeability especially in K. pneumoniae

Co-existence of blaOXA-23 and blaVIM in carbapenem-resistant Acinetobacter baumannii isolates belonging to global complex 2 in a Chinese teaching hospital.

Zi-Yan Huang et al.

Chinese medical journal, 132(10), 1166-1172 (2019-03-19)

Carbapenem-resistant Acinetobacter baumannii (CRAB) have been a challenging concern of health-care associated infections. The aim of the current study was to investigate the molecular epidemiology and clonal dissemination of CRAB isolates in a Chinese teaching hospital. Non-duplicate clinical A. baumannii

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全球贸易项目编号

货号	GTIN
PHR1796-200MG	04061835080328