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Merck
CN

SMB01383

PhIP

≥95% (HPLC)

别名:

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

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关于此项目

经验公式(希尔记法):
C13H12N4
化学文摘社编号:
分子量:
224.26
UNSPSC Code:
12352100
NACRES:
NA.28
MDL number:
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biological source

synthetic

Quality Level

assay

≥95% (HPLC)

form

solid

shipped in

2-8°C

storage temp.

2-8°C

SMILES string

NC1=NC2=NC=C(C3=CC=CC=C3)C=C2N1C

InChI

1S/C13H12N4/c1-17-11-7-10(9-5-3-2-4-6-9)8-15-12(11)16-13(17)14/h2-8H,1H3,(H2,14,15,16)

InChI key

UQVKZNNCIHJZLS-UHFFFAOYSA-N

General description

PhIP (2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine) is a dietary genotoxic carcinogen formed in heat processed meat and fish via the Maillard reaction. PhIP is a primary metabolite activated by CYP1A2 and N-acetyltransferase 1 or sulfotransferase to DNA reactive metabolite.

Biochem/physiol Actions

Carcinogen developed in grilled meats. Induces breast and colon cancer in rats.


pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

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Yueliang Zhao et al.
Journal of agricultural and food chemistry, 69(46), 13933-13941 (2021-11-11)
The effects of the deacetylation degree (DD) of chitosan on heterocyclic aromatic amine formation were investigated in chemical models and beef patties. The results in model systems showed that at lower addition levels (10 mg), chitosan with 85% DD showed



全球贸易项目编号

货号GTIN
SMB01383-10MG04065269090809