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Z1900000

齐多夫定

Name: 齐多夫定
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

3′-叠氮-3′-脱氧胸苷, AZT, ZDV, 叠氮胸苷, 齐多夫定

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₃N₅O₄

化学文摘社编号:

30516-87-1

分子量:

267.24

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329831604

MDL number:

MFCD00006536

Beilstein/REAXYS Number:

3595791

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属性

grade

pharmaceutical primary standard

API family

zidovudine

manufacturer/tradename

EDQM

mp

113-115 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Zidovudine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

对 HIV-1 病毒有效的逆转录酶抑制剂。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS08

signalword

Warning

hcodes

H341,H351

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 2 - Muta. 2

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Interaction of 3'-azido-3'-deoxythymidine with the organic base transporter in a cultured renal epithelium.

R Bendayan et al.

Pharmacotherapy, 15(3), 338-344 (1995-05-01)

In humans and various animal species, 3'-azido-3'-deoxythymidine (AZT) is in part eliminated by the kidneys, where it undergoes significant tubular secretion. The goal of this project was to develop, in a continuous renal epithelial cell line (LLCPK1), a model of

Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine.

Tomas Cihlar et al.

Antiviral research, 85(1), 39-58 (2009-11-06)

Twenty-five years ago, nucleoside analog 3'-azidothymidine (AZT) was shown to efficiently block the replication of HIV in cell culture. Subsequent studies demonstrated that AZT acts via the selective inhibition of HIV reverse transcriptase (RT) by its triphosphate metabolite. These discoveries

Tumor-specific suicide gene therapy for hepatocellular carcinoma by transcriptionally targeted retroviral replicating vectors.

Y-H Lai et al.

Gene therapy, 22(2), 155-162 (2014-10-31)

Replicating virus vectors are attractive tools for anticancer gene therapy, but the potential for adverse events due to uncontrolled spread of the vectors has been a major concern. To design a tumor-specific retroviral replicating vector (RRV), we replaced the U3

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货号	GTIN
Z1900000	04061833809259