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248M-9

Ep-CAM/Epithelial Specific Antigen (Ber-EP4) Mouse Monoclonal Antibody

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
Ber-EP4, monoclonal
Application:
IHC (p)
Citations:
6
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biological source

mouse

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

Ber-EP4, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (248M-94), vial of 0.5 mL concentrate (248M-95), bottle of 1.0 mL predilute (248M-97), vial of 1.0 mL concentrate (248M-96), bottle of 7.0 mL predilute (248M-98)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotype

IgG1κ

control

colon carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... EPCAM(4072)

General description

Epithelial cell adhesion molecule (Ep-CAM) is a transmembrane glycoprotein localized on the membrane of cells in most epithelial tissues. Immunoreactivity with the antibody to E-CAM has been seen in the majority of epithelial neoplasms, whereas most non-epithelial neoplasms do not show Ep-CAM expression. Ep-CAM is not expressed in mesothelial cells, hepatocytes, and lymphocytes. In conjunction with other markers, Ep-CAM can be used as an aid in determining the epithelial origin of neoplasms such as lung adenocarcinoma.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note


IVD
IVD
IVD
RUO

Other Notes

Ep-CAM Positive Control Slides, Product No. 248S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000292397
0000299336
0000290828
0000299337
0000299337

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At present, a large number of immunohistochemical markers that can be used in the differential diagnosis between epithelioid peritoneal mesotheliomas and serous carcinomas are available. However, great differences of opinion exist regarding the individual value of some of these markers.
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Although most studies have indicated that Ber-EP4 immunostaining can assist in differentiating epithelial pleural mesotheliomas from adenocarcinomas that metastasize to the pleura, the percentage of positive cases has varied greatly among different studies. Authors of a recent publication concluded that
Nelson G Ordóñez
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 19(3), 417-428 (2006-01-18)
As both mesotheliomas and squamous carcinomas can present a wide variety of morphological patterns, they can on occasion be confused. Recently, some groups of investigators have called attention to the difficulties that sometimes exist in distinguishing between these malignancies and
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