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42490

1,2-二油酰基-sn-丙三基-3-磷酸乙醇胺

≥99.0% (10 mg phospholipid per ml CHCl3, TLC)

别名:

3-sn-磷脂酰乙醇胺, 1,2-二油酰, L-β,γ-二油酰-α-脑磷脂, DOPE, PE(18:1(9Z)/18:1(9Z)), 二油酰磷脂酰乙醇胺

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关于此项目

经验公式（希尔记法）:
C41H78NO8P
化学文摘社编号:
4004-05-1
分子量:
744.03
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
57650115
EC Number:
200-663-8
Beilstein/REAXYS Number:
1718431
MDL number:
MFCD00057986
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Quality Level

100

assay

≥99.0% (10 mg phospholipid per ml CHCl3, TLC)

form

liquid

functional group

phospholipid

lipid type

phosphoglycerides

storage temp.

−20°C

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-

InChI key

MWRBNPKJOOWZPW-CLFAGFIQSA-N

Application

1,2-二油酰-sn-甘油-3-磷酸乙醇胺（DOPE）可与N-[1-(2,3-二油酰氧基)丙基] -N,N,N-三甲基甲基硫酸铵（DOTAP）形成异质脂质体而作为治疗剂的运载工具。

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves

法规信息

易制毒化学品（2类）
危险化学品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCB6052
BCBV0250
BCBM1838V
BCBJ3088V
BCBF1659V

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S Peraramelli et al.
Journal of thrombosis and haemostasis : JTH, 12(11), 1826-1837 (2014-08-29)
TFPI is a Kunitz-type protease inhibitor that downregulates the extrinsic coagulation pathway by inhibiting factor Xa (FXa) and FVIIa. All three Kunitz domains (KD1, KD2, and KD3) and protein S are required for optimal inhibition of FXa and FVIIa. There
Antonio A M Gasperini et al.
Langmuir : the ACS journal of surfaces and colloids, 31(11), 3308-3317 (2015-03-03)
This work presents a study of the association between low molecular weight hyaluronic acid (16 kDa HA) and cationic liposomes composed of egg phosphatidylcholine (EPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). The cationic liposome/HA complexes were evaluated to determine their mesoscopic
Emile Jubeli et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 280-289 (2014-12-24)
Cationic lipids are promising non-viral vectors for the cellular delivery of nucleic acids. Important considerations for the development of new delivery vectors are enhanced uptake efficiency, low toxicity and traceability. Traceable gene transfer systems however typically require the inclusion of
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全球贸易项目编号

货号GTIN
42490-10ML04061838169198
42490-2.5ML04061832103839