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442R-1

LEF1 (EP310) Rabbit Monoclonal Primary Antibody

Name: LEF1 (EP310) Rabbit Monoclonal Primary Antibody
Brand: SIGMA

别名:

Lymphoid Enhancing Factor 1

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关于此项目

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

EP310, monoclonal

Application:

IHC (p)

Citations:

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属性

biological source

rabbit

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP310, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (442R-14), vial of 0.1 mL concentrate Research Use Only (442R-14-RUO), vial of 0.5 mL concentrate (442R-15), vial of 1.0 mL concentrate (442R-16), vial of 1.0 mL concentrate Research Use Only (442R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (442R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (442R-17), vial of 7.0 mL pre-dilute ready-to-use (442R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (442R-18-RUO)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

small lymphocytic lymphoma, tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... LEF1(51176)

说明

General description

Lymphoid Enhancing Factor 1 (LEF1) is a transcription factor that belongs to the TCF/LEF family. LEF1 participates as a regulator in Wnt signaling pathways. LEF1 is an important factor in lymphopoiesis and is expressed normally in T and pro-B cells but not expressed in mature B cells. Strong nuclear expression of LEF1 has been observed in majority of chronic lymphocytic leukemia/small lymphocytic lymphoma cases and LEF1 is not detected in other small B cell lymphomas. Anti-LEF1 may be used as an aid for differentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma from other small B cell lymphomas.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

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Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland.

Kata Boras-Granic et al.

Developmental biology, 295(1), 219-231 (2006-05-09)

Inductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin appendages such as hair follicles and mammary glands. Lef1-mediated canonical Wnt signaling is required for morphogenesis of these skin appendages during embryogenesis. In order to define the role

全球贸易项目编号

货号	GTIN
442R-16-RUO	04061836548421