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46121

乙氧基试卤灵

Name: 乙氧基试卤灵
Brand: SIGMA

suitable for fluorescence, ≥95% (UV)

别名:

7-乙氧基-3H-吩恶嗪-3-酮, O ⁷-乙基试卤灵, 乙氧基试卤灵

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₁NO₃

化学文摘社编号:

5725-91-7

分子量:

241.24

UNSPSC Code:

12161501

NACRES:

NA.32

PubChem Substance ID:

329757074

MDL number:

MFCD00037661

Beilstein/REAXYS Number:

225973

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属性

Quality Level

100

assay

≥95% (UV)

form

solid

mp

223-225 °C (lit.)

solubility

DMF: soluble, DMSO: soluble, alcohols: soluble

fluorescence

λ_ex 464 nm; λ_em 540 nm in methanol(lit.), λ_ex 571 nm; λ_em 585 nm in dealkylase(lit.)

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F

InChI

1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3

InChI key

ZOSYTBPPLWBBKM-UHFFFAOYSA-N

说明

Application

7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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How flood events affect rainbow trout: evidence of a biomarker cascade in rainbow trout after exposure to PAH contaminated sediment suspensions.

Markus Brinkmann et al.

Aquatic toxicology (Amsterdam, Netherlands), 128-129, 13-24 (2012-12-25)

Increasing frequency and intensity of flood events are major concerns in the context of climate change. In addition to the direct hydrological implications of such events, potential ecotoxicological impacts are of increasing interest. It is vital to understand mechanisms of

Fluorescence assay for per-cell estimation of cytochrome P-450-dependent monooxygenase activities in keratinocyte suspensions and cultures.

J J Reiners et al.

Analytical biochemistry, 188(2), 317-324 (1990-08-01)

An assay was characterized that facilitated per-cell estimation of cytochrome P-450-dependent monooxygenase activities in whole-cell suspensions and cultures of murine epidermal keratinocytes (MEKs). 7-Ethoxycoumarin O-deethylase (7-ECD), 7-ethoxyresorufin O-deethylase (7-ERD), and 7-pentoxyresorufin O-deethylase (7-PRD) activities were monitored by fluorescent detection of

Ethoxyresorufin-O-deethylase (EROD) activity in fish as a biomarker of chemical exposure.

J J Whyte et al.

Critical reviews in toxicology, 30(4), 347-570 (2000-08-24)

This review compiles and evaluates existing scientific information on the use, limitations, and procedural considerations for EROD activity (a catalytic measurement of cytochrome P4501A induction) as a biomarker in fish. A multitude of chemicals induce EROD activity in a variety

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全球贸易项目编号

货号	GTIN
46121-25MG-F	04061833277218
46121-5MG-F	04061832344355