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76548

1,2-二油酰基-sn-丙三基-3-磷酸乙醇胺

Name: 1,2-二油酰基-<I>sn</I>-丙三基-3-磷酸乙醇胺
Brand: SIGMA

≥97.0% (TLC)

别名:

3-sn-磷脂酰乙醇胺, 1,2-二油酰, L-β,γ-二油酰-α-脑磷脂, DOPE, PE(18:1(9Z)/18:1(9Z)), 二油酰磷脂酰乙醇胺

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关于此项目

经验公式（希尔记法）:

C₄₁H₇₈NO₈P

化学文摘社编号:

4004-05-1

分子量:

744.03

UNSPSC Code:

51191904

NACRES:

NA.85

PubChem Substance ID:

329767176

MDL number:

MFCD00057986

Beilstein/REAXYS Number:

1718431

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属性

biological source

synthetic

Quality Level

200

assay

≥97.0% (TLC)

form

solid

functional group

amine

lipid type

phosphoglycerides

storage temp.

−20°C

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-

InChI key

MWRBNPKJOOWZPW-CLFAGFIQSA-N

说明

Application

1,2-二油酰-sn-甘油-3-磷酸乙醇胺（DOPE）可与N-[1-(2,3-二油酰氧基)丙基] -N,N,N-三甲基甲基硫酸铵（DOTAP）形成异质脂质体而作为治疗剂的运载工具。

Biochem/physiol Actions

已经发现混合膜中的 DOPE 会降低荧光寿命并增加酰基链顺序。 DOPE 是阳离子脂质体的重要组成部分，专用于将 DNA 传递到胶质肉瘤和肾细胞系（基因治疗）中。

Packaging

无底玻璃瓶。内含物在插入的融合锥体内。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

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商品

作为智能药物递送系统的刺激响应材料

通过调整的理化特性，药物递送系统可根据需要设计为可递送治疗分子的智能系统。了解有关刺激响应材料药物递送应用的更多信息。

Stimuli-Responsive Materials as Intelligent Drug Delivery Systems

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

Kidney-targeted liposome-mediated gene transfer in mice.

L W Lai et al.

Gene therapy, 4(5), 426-431 (1997-05-01)

To develop gene therapy targeted to the kidney, we compared three different routes of liposome-mediated gene delivery to the kidney in mice, ie intra-renal-pelvic, intra-renal-arterial, and intra-renal-parenchymal injections. A plasmid construct, pCMV beta gal, containing a cytomegalovirus (CMV) immediate-early gene

Interaction of an amphipathic peptide with phosphatidycholine/phosphatidylethanolamine mixed membranes.

Keisuke Shintou et al.

Biophysical journal, 93(11), 3900-3906 (2007-08-21)

The effect of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) in mixed membranes with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) on interaction with a class A amphipathic peptide, Ac-DWLKAFYDKVAEKLKEAF-NH(2) (Ac-18A-NH(2)), was investigated. The fluorescence lifetime of 2-(9-anthroyloxy)stearic acid and (2)H NMR spectra were used to evaluate the penetration of

Polymorphism of pyridinium amphiphiles for gene delivery: influence of ionic strength, helper lipid content, and plasmid DNA complexation.

Marco Scarzello et al.

Biophysical journal, 88(3), 2104-2113 (2004-12-23)

Two double-tailed pyridinium cationic amphiphiles, differing only in the degree of unsaturation of the alkyl chains, have been selected for a detailed study of their aggregation behavior, under conditions employed for transfection experiments. The transfection efficiencies of the two molecules

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全球贸易项目编号

货号	GTIN
76548-1G	04061826654545
76548-100MG	04061832923390

主要文件

1,2-二油酰基-sn-丙三基-3-磷酸乙醇胺

≥97.0% (TLC)

选择尺寸

关于此项目

biological source

Quality Level

assay

form

functional group

lipid type

storage temp.

SMILES string

InChI

InChI key

Application

Biochem/physiol Actions

Packaging

Still not finding the right product?

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

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