A2324
阿米卡星 硫酸盐
aminoglycoside antibiotic
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关于此项目
化学文摘社编号:
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
biological source
synthetic
Quality Level
form
powder
concentration
691-806 μg/mg (dry)
color
white to off-white
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria
mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
OS(O)(=O)=O.NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
InChI
1S/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8+,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
InChI key
HIBICIOPDUTNRR-BOEHXBESSA-N
General description
化学结构：氨基糖苷类
Application
阿米卡星是一种氨基糖苷类抗生素，常用于治疗耐药性分枝杆菌 。 它被用于研究抗生素的生物体定向以及耐药性 。
Biochem/physiol Actions
抗菌谱： 革兰氏阴性和革兰氏阳性菌。
阿米卡星通过与30S核糖体亚基结合并诱导mRNA误读来防止细菌蛋白质合成。
Analysis Note
阿米卡星：硫酸盐比例为1:1.8
Other Notes
保存于密闭容器内，置于干燥通风处。
氨基糖苷类抗生素。 卡那霉素的衍生物。
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
A M Lovering et al.
The Journal of antimicrobial chemotherapy, 43(5), 719-721 (1999-06-26)
Antibiotic-free human serum was spiked with known concentrations of liposomal amikacin and assayed on the Abbott TDx System, using polarization fluoroimmuno assay (PFIA) kits from Abbott Laboratories, Oxis and Sigma. Although all three kits gave a linear response, the Abbott
Luiz Fernando Feres et al.
Animal reproduction science, 193, 165-170 (2018-04-22)
The aim of the present study was to evaluate the likelihood of pregnancy of in vitro-produced (IVP) embryos from batches with distinct relative efficiencies. Data were retrospectively analyzed from 605 transvaginal ultrasonic-guided follicle aspiration sessions (OPU) followed by in vitro
Lejla Imamovic et al.
Cell, 172(1-2), 121-134 (2018-01-09)
Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A2324-5G | 04061835517978 |