A2647
腺苷5′-(β,γ-酰亚胺)三磷酸盐 锂盐 水合物
≥93% (HPLC), natural (organic), powder
别名:
β,γ-硫代腺苷5′-三磷酸盐 锂盐 水合物, AMP-PNP, ATP[β,γ-NH], App(NH)p, 腺苷酰亚胺二磷酸 锂盐 水合物
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关于此项目
经验公式（希尔记法）:
C10H17N6O12P3 · xLi+ · yH2O
化学文摘社编号:
分子量:
506.20 (free acid basis)
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Beilstein/REAXYS Number:
6047109
Assay:
≥93% (HPLC)
Biological source:
natural (organic)
Form:
powder
Solubility:
H2O: 50 mg/mL
Storage temp.:
−20°C
产品名称
腺苷5′-(β,γ-酰亚胺)三磷酸盐 锂盐 水合物, ≥93% (HPLC), powder
biological source
natural (organic)
Quality Level
assay
≥93% (HPLC)
form
powder
color
white
solubility
H2O: 50 mg/mL
shipped in
dry ice
storage temp.
−20°C
SMILES string
[Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O
InChI
1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1
InChI key
PVKSNHVPLWYQGJ-KQYNXXCUSA-N
Application
腺苷5′-(β,γ--酰亚胺)三磷酸锂盐水合物用于研究单价阳离子Li+、Na+、K+、NH4+、Rb+ 和Cs+对于核酸组分固体和溶液结构的影响。腺苷5′-(β,γ-酰亚胺)三磷酸锂盐水合物被用来确定抗抑郁药抑制干扰素-γ-诱导的小胶质细胞产生的IL-6和一氧化氮。
Biochem/physiol Actions
一种非水解性ATP类似物。AMP-PNP竞争性抑制基于ATP的酶系统，比如谷氨酰胺合成酶。它可抑制一系列需要水解ATP的酶，比如DNA拓扑异构酶Ⅱ，SV40大T抗原螺旋酶和一系列激酶。阻断ATP敏感钙依赖性钾离子通道。
Preparation Note
可以制作10mg/mL储备溶液，分装，保存在-70℃，最多可以3个月。
Disclaimer
AMP-PNP在酸性条件非常不稳定，快速水解成磷酸酰胺和无机磷酸盐。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Bryan H Schmidt et al.
Nature structural & molecular biology, 19(11), 1147-1154 (2012-10-02)
Type IIA topoisomerases control DNA supercoiling and disentangle chromosomes through a complex ATP-dependent strand-passage mechanism. Although a general framework exists for type IIA topoisomerase function, the architecture of the full-length enzyme has remained undefined. Here we present the structure of
Maria Chiara Monti et al.
Nucleic acids research, 39(18), 8052-8064 (2011-07-09)
The DNA mismatch repair protein MutS recognizes mispaired bases in DNA and initiates repair in an ATP-dependent manner. Understanding of the allosteric coupling between DNA mismatch recognition and two asymmetric nucleotide binding sites at opposing sides of the MutS dimer
Ken-ichi Miyazono et al.
Journal of bacteriology, 194(3), 607-616 (2011-11-22)
Carbon catabolite repression (CCR) is a widespread phenomenon in many bacteria that is defined as the repression of catabolic enzyme activities for an unfavorable carbon source by the presence of a preferable carbon source. In Streptomyces, secondary metabolite production often
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A2647-100MG | 04061833359570 |
| A2647-25MG | 04061833359587 |
| A2647-5MG | 04061833359594 |