C8417
N-(2-氯乙基)-N-乙基-2-溴苄胺 盐酸盐
≥98% (TLC), solid, adrenergic neurotoxin
别名:
DSP-4, N-乙基-N-(2-氯乙基)-2-溴苄胺 盐酸盐
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关于此项目
经验公式（希尔记法）:
C11H15BrClN · HCl
化学文摘社编号:
分子量:
313.06
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
Beilstein/REAXYS Number:
4020910
产品名称
N-(2-氯乙基)-N-乙基-2-溴苄胺 盐酸盐, ≥98%, solid
Quality Level
assay
≥98%
form
solid
color
white
solubility
H2O: 48 mg/mL, 0.1 M NaOH: 7 mg/mL, ethanol: soluble
SMILES string
Cl[H].CCN(CCCl)Cc1ccccc1Br
InChI
1S/C11H15BrClN.ClH/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12;/h3-6H,2,7-9H2,1H3;1H
InChI key
NDDRNRRNYOULND-UHFFFAOYSA-N
Biochem/physiol Actions
肾上腺素能神经毒素诱导中枢和外周去甲肾上腺素能神经末梢的急性和相对选择性变性。
Preparation Note
乙醇、水或0.1N NaOH溶液应在临用前配制。
Disclaimer
吸湿的。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
P Szot et al.
Neuroscience, 166(1), 279-291 (2010-01-05)
Degeneration of the noradrenergic neurons in the locus coeruleus (LC) is a major component of Alzheimer's (AD) and Parkinson's disease (PD), but the consequence of noradrenergic neuronal loss has different effects on the surviving neurons in the two disorders. Therefore
Ee Peng Lim et al.
The international journal of neuropsychopharmacology, 13(9), 1219-1231 (2010-02-05)
Stimulation of the subiculum/CA1 of the hippocampal formation evokes monosynaptic field potentials in the prefrontal cortex (PFC). High-frequency stimulation of the hippocampus (HPC) can induce long-term potentiation (LTP) in this hippocampo-prefrontal cortical (hippo-PFC) pathway. Previous studies have shown that dopamine
Harald Engler et al.
Journal of neuroimmunology, 219(1-2), 75-80 (2009-12-25)
The neurotransmitter noradrenaline (NA) plays a pivotal role in immune regulation. Here we used the selective neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) to investigate the impact of central NA depletion on cytokine production by splenic monocytes/macrophages and T cells. Intraperitoneal administration of DSP-4
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C8417-100MG | 04061833522295 |
| C8417-250MG | 04061832090009 |