D0156
脱氧雪腐镰刀菌烯醇
Protein synthesis inhibitor, powder
别名:
3α,7α,15-三羟基-12,13-环氧单端孢霉-9-烯-8-酮, 呕吐毒素
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关于此项目
经验公式（希尔记法）:
C15H20O6
化学文摘社编号:
分子量:
296.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder
Quality level:
产品名称
脱氧雪腐镰刀菌烯醇,
form
powder
Quality Level
storage temp.
2-8°C
SMILES string
[H][C@]12O[C@]3([H])[C@H](O)C[C@@](C)([C@]34CO4)[C@@]1(CO)[C@H](O)C(=O)C(C)=C2
InChI
1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
InChI key
LINOMUASTDIRTM-QGRHZQQGSA-N
General description
脱氧雪腐镰刀菌烯醇(DON)是一种天然霉菌毒素，存在于禾谷镰刀菌(Fusarium graminearum)和大黄镰刀菌( Fusarium culmorum)中。它属于霉菌毒素的B类单端孢霉烯毒素家族。
Application
脱氧雪腐镰刀菌烯醇已用于：
- 用作霉菌毒素，诱导猪空肠上皮细胞的细胞毒性，研究酿酒酵母(Saccharomyces cerevisiae)对宿主细胞活力的保护作用。
- 诱导裸鼠毒性，研究补充益生菌（鼠李糖乳杆菌GG (LGG)或嗜酸乳杆菌 (LA)对于宿主细胞的作用
- 用作细胞荧光素酶报告基因(CALUX)测定中的甲状腺激素受体(TR)拮抗剂
Biochem/physiol Actions
脱氧雪腐镰刀菌烯醇(DON)通过抑制翻译过程，阻断DNA和RNA合成。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
高风险级别生物产品--毒素类产品
此项目有
Yang Liu et al.
AMB Express, 9(1), 137-137 (2019-09-05)
Deoxynivalenol (DON) is one of the mycotoxins most frequently encountering in cereal-based foods throughout the world. Saccharomyces cerevisiae was used to alleviate porcine jejunal epithelia cell (IPEC-J2) injury induced by DON in this study. The results indicated that cell viability
Xu Ji et al.
Toxins, 12(1) (2019-12-22)
To explore the protective role of hydrogen gas (H2) on oxidative damage and apoptosis in intestinal porcine epithelial cells (IPEC-J2) induced by deoxynivalenol (DON), cells were assigned to four treatment groups, including control, 5 μM DON, H2-saturated medium, and 5
Isabel Parraga-Aguado et al.
Journal of environmental management, 158, 74-84 (2015-05-13)
Phytomanagement in terms of phytostabilisation has been proposed as a suitable technique to decrease the environmental risks of metal(loid) enriched mine tailings. Nevertheless, at these sites some issues must be solved to assure the long-term establishment of vegetation (e.g. salinity
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D0156-5MG | 04061838445919 |
| D0156-1MG | 04061838445902 |