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E1406

恩贝酸

Name: 恩贝酸
Brand: SIGMA

≥98% (HPLC), powder

别名:

2,5-二羟基-3-十一烷基-2,5-环己二烯-1,4-二酮, 恩贝灵, 恩贝酸

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关于此项目

经验公式（希尔记法）:

C₁₇H₂₆O₄

化学文摘社编号:

550-24-3

分子量:

294.39

NACRES:

NA.77

PubChem Substance ID:

24724473

UNSPSC Code:

12352200

EC Number:

208-979-8

MDL number:

MFCD00016369

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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属性

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

DMSO: >10 mg/mL, H₂O: insoluble

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, parasites

mode of action

DNA synthesis | interferes

SMILES string

CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O

InChI

1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3

InChI key

IRSFLDGTOHBADP-UHFFFAOYSA-N

Gene Information

human ... XIAP(331)

说明

General description

恩贝酸是一种天然的苯醌衍生物，最早从白花酸滕果植物中提取。它在结构上类似于泛醌。

Application

使用恩贝酸：

研究其对活化T细胞(NFATc1)荧光素酶活性的核因子kB配体(RANKL)诱导的核因子的受体激活剂的影响
研究其在介导帕金森病(PD)机制中的作用′
治疗全鼠胚胎，以确定其对X连锁抑制细胞凋亡蛋白(XIAP)活性的影响

Biochem/physiol Actions

恩贝酸（Embelin）是XIAP（X连锁凋亡抑制蛋白）的抑制剂；体内抗肿瘤和抗炎活性。

恩贝酸具有抗氧化、线粒体解耦联和抗生育特性。它还具有抗糖尿病、抗惊厥、抗焦虑和抗微生物活性等作用。恩贝酸是一种有效的神经保护剂，也可作为脑卒中的辅助治疗。

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pictograms

GHS08

signalword

Warning

hcodes

H361f

pcodes

P201 - P308 + P313

Hazard Classifications

Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

NF-κB and Inflammation

Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.

Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway.

Simone Reuter et al.

Molecular cancer research : MCR, 8(10), 1425-1436 (2010-09-10)

Most patients with cancer die not because of the tumor in the primary site, but because it has spread to other sites. Common tumors, such as breast, multiple myeloma, and prostate tumors, frequently metastasize to the bone. It is now

XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells.

Jennifer L Allensworth et al.

Molecular cancer therapeutics, 11(7), 1518-1527 (2012-04-18)

We recently identified superoxide dismutase (SOD) overexpression and decreased induction of reactive oxygen species (ROS)-mediated apoptosis in models of inflammatory breast cancer (IBC) cells with acquired therapeutic resistance. This population of cells has high expression of X-linked inhibitor of apoptosis

Synthesis and evaluation of analgesic and anti-inflammatory activities of most active free radical scavenging derivatives of embelin-A structure-activity relationship.

Sekar Mahendran et al.

Chemical & pharmaceutical bulletin, 59(8), 913-919 (2011-08-02)

Antioxidant and related properties of the plant Embelia ribes and embelin are well known. In the present study embelin was condensed with various aromatic substituted primary amines to yield ten new and one reported derivatives along with monomethyl embelin. All

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全球贸易项目编号

货号	GTIN
E1406-10MG	04061833601792
E1406-50MG	04061833601808