F7807
Prostaglandin F Synthase human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
别名:
17-beta-hydroxysteroid dehydrogenase type 5, AKR1C3, aldo-keto reductase family 1 member C3, indanol dehydrogenase
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关于此项目
化学文摘社编号:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
Specific activity:
≥0.4 μmol/mg protein
Assay:
≥90% (SDS-PAGE)
Recombinant:
expressed in E. coli
recombinant
expressed in E. coli
Quality Level
description
contains a C-terminal hexahistidine tag
assay
≥90% (SDS-PAGE)
form
liquid
specific activity
≥0.4 μmol/mg protein
mol wt
~37 kDa
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... AKR1C3(8644)
Application
Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .
Biochem/physiol Actions
PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .
Other Notes
One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37°C in 50 mM KPO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Trevor M Penning et al.
Annals of the New York Academy of Sciences, 1155, 33-42 (2009-03-03)
Prostate and breast cancer are hormone-dependent malignancies of the aging male and female and require the local production of androgens and estrogens to stimulate cell proliferation. Aldo-keto reductases (AKR) play key roles in this process. In the prostate, AKR1C3 (type
[Prostaglandin synthases with thioredoxin domain].
Kikuko Watanabe
Seikagaku. The Journal of Japanese Biochemical Society, 82(11), 1041-1046 (2011-01-14)
R J Phillips et al.
Molecular human reproduction, 17(1), 1-13 (2010-07-03)
Prostaglandins (PGs) are important factors in the physiology of human parturition and the control of uterine contractility. We have characterized the expression of 15 genes from all stages of the PG pathway in human pregnant and non-pregnant (NP) myometrium and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F7807-50UG | 04061832729527 |