biological source
fish cartilage (shark)
Quality Level
product line
BioReagent
assay
≥99%
technique(s)
cell culture | mammalian: suitable
impurities
Glucosamine, essentially free
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
shipped in
ambient
storage temp.
room temp
SMILES string
Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
InChI
1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
InChI key
CBOJBBMQJBVCMW-NQZVPSPJSA-N
Application
使用D-(+)-半乳糖胺盐:
- 诱导小鼠肝损伤
- 炎症性肝损伤
- 急性肝衰竭(ALF)
Biochem/physiol Actions
半乳糖胺(D-GalN)由半乳糖合成,是一种潜在的肝毒剂。D-GalN与脂多糖结合可导致致命性肝损伤和肝衰竭的恶化。它使细胞对细胞因子,特别是肿瘤坏死因子(TNF)的毒性作用变得敏感。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Voluntary distance running prevents TNF-mediated liver injury in mice through alterations of the intrahepatic immune milieu
Huber Y, et al.
Cell Death & Disease, 8(6), e2893-e2893 (2017)
D-galactosamine lethality model: scope and limitations
Silverstein R
Journal of endotoxin research, 10(3), 147-162 (2004)
Catalpol protects mice against Lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response
Zhang H, et al.
Testing, 9(3), 3887-3887 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G1639-1G | 04061833628300 |
| G1639-100MG | 04061833628294 |
| G1639-5G | 04061833628317 |