I0160
亚胺培南 一水合物
≥98% (HPLC), B-lactam antibiotic, powder
别名:
Primaxin 一水合物, Tienam 一水合物, （5R，6S）-6-[（（1R）-1-羟基乙基] -3-[[2-[（亚氨基甲基）氨基]乙基]硫代] -7-氧代-1-氮杂双环[3.2.0] hept-2 -烯-2-羧酸 一水合物
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关于此项目
经验公式（希尔记法）:
C12H17N3O4S · H2O
化学文摘社编号:
分子量:
317.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
264-734-5
MDL number:
产品名称
亚胺培南 一水合物, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
antibiotic activity spectrum
mycobacteria
mode of action
cell wall synthesis | interferes
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
storage temp.
−20°C
SMILES string
O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O
InChI
1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1
InChI key
GSOSVVULSKVSLQ-JJVRHELESA-N
General description
Chemical structure: β-lactam
Application
Imipenem monohydrate has been used to determine the resistance profiles of Pseudomonas aeruginosa isolates. It has also been used in susceptibility testing against Acinetobacter baumannii.
Biochem/physiol Actions
Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.
亚胺培南一水合物是广谱 B -内酰胺抗生素。
亚胺培南一水合物是广谱 B -内酰胺抗生素。 它是碳青霉烯类“魔弹”抗生素的一种，用于严重感染。
Features and Benefits
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Efficacy of imipenem/cilastatin in endocarditis
Dickinson G, et al.
The American Journal of Medicine, 78(6), 117-121 (1985)
Could plazomicin alone or in combination be a therapeutical option against carbapenem-resistant Acinetobacter baumannii?
Garcia Salguero C, et al.
Antimicrobial Agents and Chemotherapy, AAC-00873 (2015)
Stefania Correale et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 9), 1697-1706 (2013-09-04)
The modelling of peptidoglycan is responsible for key cellular processes in Mycobacterium tuberculosis such as cell growth, division and resuscitation from dormancy. The structure of M. tuberculosis peptidoglycan is atypical since it contains a majority of 3,3 cross-links synthesized by L,D-transpeptidases
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I0160-25MG | 04061835304813 |
| I0160-5MG | 04061835304820 |