I0523
IL-2 mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
别名:
mIL-2, IL-2, T细胞生长因子
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关于此项目
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
≥97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
17.2 kDa
Impurities:
≤1.000 EU/μg
产品名称
白细胞介素-2 来源于小鼠, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
mouse
Quality Level
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
≤0.2 ng/mL ED50
quality
endotoxin tested
mol wt
17.2 kDa
packaging
pkg of 5X20 μg, pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/μg
color
white
UniProt accession no.
storage temp.
−20°C
General description
IL-2（白介素2）编码促炎性细胞因子。 IL-2主要在辅助性T细胞中表达。
Application
来自小鼠的白介素-2已被用于诱导大鼠模型的败血症。 它还被用于树突状表皮T细胞培养。
Biochem/physiol Actions
白细胞介素2（IL-2）是由T淋巴细胞的某些亚群产生的免疫调节因子。该淋巴因子可促进活化T细胞和相关细胞类型的长期生长。IL-2在自然杀伤细胞的激活和增殖中发挥作用、诱导γ-干扰素和B细胞生长因子的分泌，并调节IL-2受体的表达。已知IL-2表达会随着年龄的增长而降低，并导致流感病毒感染、肿瘤和致死性自身免疫。IL-2参与T细胞的增殖和分化，并控制T细胞的稳态。作为免疫应答的一部分，IL-2能够刺激辅助性T细胞1和2以及骨骼肌的内皮白细胞。IL-2调节受到c-rel蛋白的控制。IL-2是一种神经营养分子，在皮层、海马、中隔、小脑和视网膜神经元中具有特殊功能。
Physical form
从 0.2 μm 过滤的 10mM 柠檬酸钠溶液 (pH 4.0) 中冻干。
Analysis Note
通过对鼠CTLL-2细胞进行剂量依赖性刺激来测定活性。 ED50： ≤ 0.2 ng/ml（相当于5 × 106 单位/mg的比活度）
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
Decreased c-rel activation contributes to aberrant interleukin-2 expression in CD4+ T cells of aged rats
Gong Z, et al.
Molecular Immunology, 61, 1-6 (2014)
Protein kinases JAK and ERK mediate protective effect of interleukin-2 upon ganglion cells of the developing rat retina
Marra C, et al.
Journal of Neuroimmunology, 233(1-2), 120-126 (2011)
Acute exhaustive exercise regulates IL-2, IL-4 and MyoD in skeletal muscle but not adipose tissue in rats
Neto JCR, et al.
Lipids in Health and Disease, 10, 97-97 (2011)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I0523-20UG | 04061833837917 |
| I0523-5X20UG | 04061833837955 |