I3036
聚肌苷酸-聚胞苷酸 钾盐
γ-irradiated, 10% Poly (I:C) with buffer salts, TLR ligand tested
别名:
Poly (I:C), Poly(I) • Poly(C)
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Assay:
≥99% (TLC)
Quality level:
Biochem/physiol Actions
将Poly(I:C)转染至NIT-1细胞中，已被用作细胞内dsRNA诱导的β细胞凋亡的模型。转染后18小时，45％的细胞发生凋亡，并且其NF-kB、p50/p65核转位、caspase 3和8切割以及caspase 12的转录诱导、Fas、IL-15和TNF受体相关配体（TRAIL）水平均增加。有人提出Poly(I:C)是最合适的稳定成熟树突状细胞（DC）诱导剂之一。这些成熟DC能够在CD40连接后分泌生物活性IL-12，因此注射后能够在体内产生有效的免疫应答。Poly(I:C)被用作有效的佐剂，以增强对肽类疫苗的特异性抗肿瘤免疫应答。
Packaging
包装规格取决于多核苷酸含量
Physical form
10％ 聚（I：C）与氯化钠和磷酸钠缓冲盐
Other Notes
双链均聚物。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Lingjun Meng et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(35), 11007-11012 (2015-08-19)
Systematic inflammation contributes to the development of many diseases, including cardiovascular disease, which is the leading cause of mortality worldwide. How such inflammation is initiated and maintained throughout the course of disease remains unclear. In the current study, we report
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I3036-20MG | 04061833253441 |
| I3036-2MG | 04061833848838 |