I5403
Insulin-Like Growth Factor Binding Protein-2 human
recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)
别名:
IGFBP-2
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关于此项目
biological source
human
Quality Level
recombinant
expressed in NSO cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
0.04 μg/mL
mol wt
~36 kDa by SDS-PAGE, calculated mol wt ~31 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IGFBP2(3485)
General description
The gene IGFBP-2 (insulin-like growth factor binding protein-2) is mapped to human chromosome 2q35.
Biochem/physiol Actions
During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
Exhibits a 2-10 fold higher affinity for IGF II than for IGF I.
IGFBP-2 (insulin-like growth factor binding protein-2) regulates the function of IGF ligands. IGFBP2 is associated with skeletal muscle cell proliferation and differentiation. It also plays an important role in the differentiation of corneal fibroblast.
Physical form
Lyophilized from a 0.2 μm filtered solution of 30% (v/v) acetonitrile with 0.1% (v/v) TFA
Analysis Note
The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
常规特殊物品
此项目有
Soo Hyun Park et al.
Investigative ophthalmology & visual science, 56(12), 7293-7302 (2015-11-13)
Previously, we reported that keratocyte-conditioned medium (KCM) facilitates the differentiation of human mesenchymal stem cells (hMSCs) into corneal keratocyte-like cells. This study is designed to investigate the roles of insulin-like growth factor binding protein 2 (IGFBP2) for the regulation of
Chad P Garner et al.
Human genetics, 123(3), 247-255 (2008-01-23)
The insulin-like growth factor (IGF) signaling pathway is thought to play a major role in the etiology of breast cancer. Although incidence rates of breast cancer overall are lower in African Americans than in Caucasians, African-American women have a higher
H Yu et al.
Journal of clinical laboratory analysis, 13(4), 166-172 (1999-07-22)
Insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) play an important role in cell growth and differentiation. Clinical and epidemiological studies have indicated that measuring IGFs and IGFBPs in blood has potential implications in assessing growth-related abnormalities and risks
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I5403-25UG | 04061833857342 |