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L9668

Lidoflazine

Name: Lidoflazine
Brand: SIGMA

≥98% (HPLC), powder

别名:

4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide

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关于此项目

经验公式（希尔记法）:

C₃₀H₃₅F₂N₃O

化学文摘社编号:

3416-26-0

分子量:

491.62

NACRES:

NA.77

PubChem Substance ID:

329817673

UNSPSC Code:

12352200

EC Number:

222-312-8

MDL number:

MFCD00057353

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2

InChI

1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)

InChI key

ZBIAKUMOEKILTF-UHFFFAOYSA-N

说明

Biochem/physiol Actions

HERG calcium channel blocker

Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC₅₀ < 0.1 μM

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

127K4606V

127K46061

127K4606

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Effects of lidoflazine on left ventricular function in patients.

S G De Hert et al.

Journal of cardiothoracic and vascular anesthesia, 11(1), 42-48 (1997-02-01)

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